<br>TBP 相关因子 (TAF) 参与细胞分化,Journal of Cellular Physiology

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TBP 相关因子 (TAF) 参与细胞分化
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2023-12-21 , DOI: 10.1002/jcp.31167
Juan Pedro Luna-Arias ₁ , Federico Castro-Muñozledo ₁

Affiliation

了解调节基因表达以建立分化程序和确定细胞谱系的机制是发育生物学的主要挑战之一。除了组织特异性转录因子和表观遗传过程的参与外，一般转录因子的作用被忽略了。只是近年来，针对这一问题的研究还很少。在此，我们综述了一些TATA盒结合蛋白（TBP）相关因子（TAF）在干/祖细胞增殖过程中的生物学活性及其参与细胞分化的研究。特别是，积累的证据表明TAF4、TAF4b、TAF7L、TAF8、TAF9和TAF10等参与神经系统发育、脂肪生成、肌生成和表皮分化；而TAF1、TAF7、TAF15可能参与干细胞增殖能力和细胞周期进程的调节。另一方面，有证据表明，TBP 变异体（例如 TBPL1 和 TBPL2）可能调节一些发育过程，例如生殖细胞成熟和分化、肌发生或发育过程中的腹侧规范。我们的分析表明，有必要更深入地研究这些因子的生物学功能及其对特定转录复合物组装的参与，这些转录复合物有助于差异基因表达，从而导致生物体中存在的细胞类型的巨大多样性。对 TAF 调节的理解可能会导致针对转录机制这些基本元件发生突变、改变和失调的患者开发新疗法。

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Participation of the TBP-associated factors (TAFs) in cell differentiation

The understanding of the mechanisms that regulate gene expression to establish differentiation programs and determine cell lineages, is one of the major challenges in Developmental Biology. Besides the participation of tissue-specific transcription factors and epigenetic processes, the role of general transcription factors has been ignored. Only in recent years, there have been scarce studies that address this issue. Here, we review the studies on the biological activity of some TATA-box binding protein (TBP)-associated factors (TAFs) during the proliferation of stem/progenitor cells and their involvement in cell differentiation. Particularly, the accumulated evidence suggests that TAF4, TAF4b, TAF7L, TAF8, TAF9, and TAF10, among others, participate in nervous system development, adipogenesis, myogenesis, and epidermal differentiation; while TAF1, TAF7, TAF15 may be involved in the regulation of stem cell proliferative abilities and cell cycle progression. On the other hand, evidence suggests that TBP variants such as TBPL1 and TBPL2 might be regulating some developmental processes such as germ cell maturation and differentiation, myogenesis, or ventral specification during development. Our analysis shows that it is necessary to study in greater depth the biological function of these factors and its participation in the assembly of specific transcription complexes that contribute to the differential gene expression that gives rise to the great diversity of cell types existing in an organism. The understanding of TAFs' regulation might lead to the development of new therapies for patients which suffer from mutations, alterations, and dysregulation of these essential elements of the transcriptional machinery.

更新日期：2023-12-21

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