Triazole groups play an important role in the construction of agricultural bioactive molecules, often acting as linking units to organically graft different pharmacophore groups, so as to obtain efficient and broad-spectrum pesticide molecules. After decades of development, triazole derivatives have made remarkable achievements in the discovery of pesticides, especially the discovery of fungicides. In addition, highly effective triazole insecticides, herbicides, and anti-plant virus agents have also been found, and commercial triazole pesticides have occupied a large market share. At present, the study of triazole compounds has become one of the important fields in the development of new pesticides. We systematically reviewed the application of triazole derivatives in the discovery of new pesticides since 2010, summarized the antifungal, antibacterial, insecticidal, herbicidal, and anti-plant virus activities of triazole derivatives, and discussed the structure–activity relationship and mechanism of action in order to provide inspiration and ideas for the discovery of new triazole agrochemicals.

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三唑衍生物在农用化学品发现中的研究进展

三唑基团在农业生物活性分子的构建中发挥着重要作用，常作为连接单元有机接枝不同的药效基团，从而获得高效、广谱的农药分子。经过几十年的发展，三唑衍生物在农药的发现，特别是杀菌剂的发现方面取得了令人瞩目的成就。此外，还发现了高效的三唑类杀虫剂、除草剂、抗植物病毒剂，商品化的三唑类农药已经占据了很大的市场份额。目前，三唑类化合物的研究已成为新型农药开发的重要领域之一。我们系统回顾了2010年以来三唑衍生物在新农药发现中的应用，总结了三唑衍生物的抗真菌、抗菌、杀虫、除草、抗植物病毒活性，并探讨了其构效关系和作用机制。为新型三唑类农药的发现提供灵感和思路。