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Focusing on the Abnormal Events of NPC1, NPC2, and NPC1L1 in Pan-Cancer and Further Constructing LUAD and KICH Prediction Models
Journal of Proteome Research ( IF 3.8 ) Pub Date : 2023-12-18 , DOI: 10.1021/acs.jproteome.3c00655
Keheng Chen 1 , Xin Zhang 2 , Guangyu Sun 3 , Zhichao Fang 3 , Lusheng Liao 2 , Yanping Zhong 2 , Fengdie Huang 2 , Mingyou Dong 1 , Shihua Luo 4
Journal of Proteome Research ( IF 3.8 ) Pub Date : 2023-12-18 , DOI: 10.1021/acs.jproteome.3c00655
Keheng Chen 1 , Xin Zhang 2 , Guangyu Sun 3 , Zhichao Fang 3 , Lusheng Liao 2 , Yanping Zhong 2 , Fengdie Huang 2 , Mingyou Dong 1 , Shihua Luo 4
Affiliation
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Cancer’s high incidence and death rate jeopardize human health and life, and it has become a global public health issue. Some members of NPCs have been studied in a few cancers, but comprehensive and prognostic analysis is lacking in most cancers. In this study, we used the Cancer Genome Atlas (TCGA) data genomics and transcriptome technology to examine the differential expression and prognosis of NPCs in 33 cancer samples, as well as to investigate NPCs mutations and their effect on patient prognosis and to evaluate the methylation level of NPCs in cancer. The linked mechanisms and medication resistance were subsequently investigated in order to investigate prospective tumor therapy approaches. The relationships between NPCs and immune infiltration, immune cells, immunological regulatory substances, and immune pathways were also investigated. Finally, the LUAD and KICH prognostic prediction models were built using univariate and multivariate COX regression analysis. Additionally, the mRNA and protein levels of NPCs were also identified.
中文翻译：
关注泛癌中NPC1、NPC2、NPC1L1的异常事件，进一步构建LUAD和KICH预测模型
癌症的高发病率和死亡率危害着人类的健康和生命，已成为全球性的公共卫生问题。 NPC 的一些成员已在几种癌症中进行了研究，但大多数癌症缺乏全面的预后分析。在本研究中，我们利用癌症基因组图谱（TCGA）数据基因组学和转录组技术检查了33个癌症样本中NPC的差异表达和预后，并研究了NPC的突变及其对患者预后的影响并评估了甲基化癌症中 NPC 的水平。随后研究了相关机制和耐药性，以研究前瞻性肿瘤治疗方法。还研究了NPC与免疫浸润、免疫细胞、免疫调节物质和免疫途径之间的关系。最后，利用单变量和多变量COX回归分析建立了LUAD和KICH预后预测模型。此外，还鉴定了 NPC 的 mRNA 和蛋白质水平。
更新日期：2023-12-18
中文翻译：
关注泛癌中NPC1、NPC2、NPC1L1的异常事件，进一步构建LUAD和KICH预测模型
癌症的高发病率和死亡率危害着人类的健康和生命，已成为全球性的公共卫生问题。 NPC 的一些成员已在几种癌症中进行了研究，但大多数癌症缺乏全面的预后分析。在本研究中，我们利用癌症基因组图谱（TCGA）数据基因组学和转录组技术检查了33个癌症样本中NPC的差异表达和预后，并研究了NPC的突变及其对患者预后的影响并评估了甲基化癌症中 NPC 的水平。随后研究了相关机制和耐药性，以研究前瞻性肿瘤治疗方法。还研究了NPC与免疫浸润、免疫细胞、免疫调节物质和免疫途径之间的关系。最后，利用单变量和多变量COX回归分析建立了LUAD和KICH预后预测模型。此外，还鉴定了 NPC 的 mRNA 和蛋白质水平。
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