Free-Standing Carbon Nanotube Embroidered Graphene Film Electrode Array for Stable Neural Interfacing,Nano Letters

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Free-Standing Carbon Nanotube Embroidered Graphene Film Electrode Array for Stable Neural Interfacing
Nano Letters ( IF 9.6 ) Pub Date : 2023-12-20 , DOI: 10.1021/acs.nanolett.3c03421
Lei Gao _{1,

2} , Suye Lv _{1,

3} , Yuanyuan Shang ₄ , Shouliang Guan ₁ , Huihui Tian ₁ , Ying Fang _{1,

2,

3,

5} , Jinfen Wang ₁ , Hongbian Li _{1,

6}

Affiliation

Implantable neural probes that are mechanically flexible yet robust are attractive candidates for achieving stable neural interfacing in the brain. Current flexible neural probes consist mainly of metal thin-film electrodes integrated on micrometer-thick polymer substrates, making it challenging to achieve electrode-tissue interfacing on the cellular scale. Here, we describe implantable neural probes that consist of robust carbon nanotube network embroidered graphene (CeG) films as free-standing recording microelectrodes. Our CeG film microelectrode arrays (CeG_MEAs) are ultraflexible yet mechanically robust, thus enabling cellular-scale electrode-tissue interfacing. Chronically implanted CeG_MEAs can stably track the activities of the same population of neurons over two months. Our results highlight the potential of ultraflexible and free-standing carbon nanofilms for stable neural interfacing in the brain.

中文翻译：

用于稳定神经接口的独立式碳纳米管刺绣石墨烯薄膜电极阵列

机械灵活且坚固的可植入神经探针是在大脑中实现稳定神经接口的有吸引力的候选者。目前的柔性神经探针主要由集成在微米厚的聚合物基底上的金属薄膜电极组成，这使得在细胞尺度上实现电极-组织接口具有挑战性。在这里，我们描述了由坚固的碳纳米管网络刺绣石墨烯（CeG）薄膜组成的可植入神经探针作为独立式记录微电极。我们的 CeG 薄膜微电极阵列 (CeG_MEA) 具有超柔性且机械坚固性，从而实现细胞规模的电极-组织接口。长期植入的 CeG_MEA 可以在两个月内稳定地跟踪同一群神经元的活动。我们的研究结果凸显了超柔性和独立式碳纳米膜在大脑稳定神经接口方面的潜力。

更新日期：2023-12-20

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