Molecular Biology Reports ( IF 2.6 ) Pub Date : 2023-12-21 , DOI: 10.1007/s11033-023-09045-5
Ali Afzal 1, 2 , Muhammad Babar Khawar 2, 3 , Ume Habiba 4 , Hanan Afzal 1 , Syeda Eisha Hamid 1 , Mussarat Rafiq 5 , Muddasir Hassan Abbasi 6 , Nadeem Sheikh 5 , Rimsha Abaidullah 3 , Zoya Asif 3 , Tahaa Saeed 7
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Extracellular vesicles (EVs) are membrane-derived messengers which have been playing an important role in the inflammation and pathogenesis of lung diseases. EVs contain varieties of DNA, RNA, and membrane receptors through which they work as a delivery system for bioactive molecules as well as intracellular communicators. EV signaling mediates tumor progression and metastasis. EVs are linked with many diseases and perform a diagnostic role in lung injury and inflammation so are used to diagnose the severity of diseases. EVs containing a variety of biomolecules communicate with the recipient cells during pathophysiological mechanisms thereby acquiring the attention of clinicians toward the diagnostic and therapeutic potential of EVs in different lung diseases. In this review, we summarize the role of EVs in inflammation with an emphasis on their potential as a novel candidate in the diagnostics and therapeutics of chronic obstructive pulmonary disease, asthma, and sarcoidosis.
中文翻译:
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EV 在肺部疾病和炎症中的诊断和治疗价值
细胞外囊泡 (EVs) 是膜衍生的信使,在肺部疾病的炎症和发病机制中一直发挥着重要作用。EV 包含多种 DNA、RNA 和膜受体,它们通过这些受体作为生物活性分子的递送系统以及细胞内通讯器。EV 信号转导介导肿瘤进展和转移。EV 与许多疾病有关,并在肺损伤和炎症中起诊断作用,因此用于诊断疾病的严重程度。含有多种生物分子的 EV 在病理生理机制中与受体细胞进行通信,从而引起临床医生对 EV 在不同肺部疾病中的诊断和治疗潜力的关注。在这篇综述中,我们总结了 EVs 在炎症中的作用,并强调了它们作为慢性阻塞性肺病、哮喘和结节病诊断和治疗的新型候选药物的潜力。