<br>高生物适应性骨组织工程支架 3D 打印的进展,ACS Biomaterials Science & Engineering

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高生物适应性骨组织工程支架 3D 打印的进展
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2023-12-20 , DOI: 10.1021/acsbiomaterials.3c01129
Ya Ren _{1,

2,

3} , Changru Zhang ₃ , Yihao Liu ₃ , Weiqing Kong ₄ , Xue Yang ₂ , Haoyi Niu ₃ , Lei Qiang ₅ , Han Yang ₆ , Fei Yang ₃ , Chengwei Wang ₃ , Jinwu Wang _{1,

2,

3}

Affiliation

外伤、骨肿瘤、骨质疏松等引起的骨缺损患者数量大幅增加。不规则、复发性、大面积骨缺损的修复给临床医生带来了巨大的挑战。骨组织工程正在成为替代自体骨移植修复临界尺寸骨缺损的适当策略。然而，骨组织工程支架在结构、力学、降解、微环境等方面的适用性还不够。三维（3D）打印是一种广泛用于骨修复的先进增材制造技术。 3D 打印根据 CT 图像重建的 3D 模型构建个性化的结构适应支架。通过改变堆叠结构来解决力学与退化之间的矛盾。通过设计内部孔隙结构和时空因子释放系统，改善种植体的局部微环境。因此，个性化骨修复支架的3D打印出现了热潮。在这篇综述中，介绍了利用3D打印制备高生物适应性骨组织工程支架的成功研究。阐明骨假体的结构、力学、降解和微环境适应机制及其相互作用，为构建高度生物适应性的骨组织工程支架提供可行的策略。

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Advances in 3D Printing of Highly Bioadaptive Bone Tissue Engineering Scaffolds

The number of patients with bone defects caused by trauma, bone tumors, and osteoporosis has increased considerably. The repair of irregular, recurring, and large bone defects poses a great challenge to clinicians. Bone tissue engineering is emerging as an appropriate strategy to replace autologous bone grafting in the repair of critically sized bone defects. However, the suitability of bone tissue engineering scaffolds in terms of structure, mechanics, degradation, and the microenvironment is inadequate. Three-dimensional (3D) printing is an advanced additive-manufacturing technology widely used for bone repair. 3D printing constructs personalized structurally adapted scaffolds based on 3D models reconstructed from CT images. The contradiction between the mechanics and degradation is resolved by altering the stacking structure. The local microenvironment of the implant is improved by designing an internal pore structure and a spatiotemporal factor release system. Therefore, there has been a boom in the 3D printing of personalized bone repair scaffolds. In this review, successful research on the preparation of highly bioadaptive bone tissue engineering scaffolds using 3D printing is presented. The mechanisms of structural, mechanical, degradation, and microenvironmental adaptations of bone prostheses and their interactions were elucidated to provide a feasible strategy for constructing highly bioadaptive bone tissue engineering scaffolds.

更新日期：2023-12-20

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