<br>通过半透明光学引导实现多尺度体积动态光声和激光超声（OPLUS）成像,Advanced Science

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通过半透明光学引导实现多尺度体积动态光声和激光超声（OPLUS）成像
Advanced Science ( IF 14.3 ) Pub Date : 2023-12-20 , DOI: 10.1002/advs.202306087
Daniil Nozdriukhin _{1,

2} , Sandeep Kumar Kalva _{1,

2} , Cagla Özsoy _{1,

2} , Michael Reiss _{1,

2} , Weiye Li _{1,

2} , Daniel Razansky _{1,

2} , Xosé Luís Deán-Ben _{1,

2}

Affiliation

重大的生物学发现是通过用光询问生物体而取得的。然而，未散射光子在生物组织中的有限穿透限制了光学方法覆盖的深度范围。深层组织成像是通过结合光和超声来实现的。光声成像利用超声波的光学生成，在光学显微镜无法达到的深度上呈现高分辨率图像。最近，激光超声被提议作为产生宽带声波的一种方法，用于高分辨率脉冲回波超声成像。在此，提出了一种基于具有受控透明度的二氧化硅光纤逐层涂层，用光和超声同时询问生物组织的方法。利用光声和使用定制球形阵列换能器收集的超声信号之间的时间分离，通过单个激光脉冲同时进行 3D 光声和激光超声（OPLUS）成像。OPLUS 被证明能够对组织进行大规模解剖学表征，以及发色团的功能多光谱成像，并以仅受激光脉冲重复频率限制的超快速率评估心脏动力学。所建议的方法为开发新一代系统提供了一种灵活且可扩展的方法，将光声学和超声成像在生物学和医学中的强大功能协同结合。

"点击查看英文标题和摘要"

Multi-Scale Volumetric Dynamic Optoacoustic and Laser Ultrasound (OPLUS) Imaging Enabled by Semi-Transparent Optical Guidance

Major biological discoveries are made by interrogating living organisms with light. However, the limited penetration of un-scattered photons within biological tissues limits the depth range covered by optical methods. Deep-tissue imaging is achieved by combining light and ultrasound. Optoacoustic imaging exploits the optical generation of ultrasound to render high-resolution images at depths unattainable with optical microscopy. Recently, laser ultrasound has been suggested as a means of generating broadband acoustic waves for high-resolution pulse-echo ultrasound imaging. Herein, an approach is proposed to simultaneously interrogate biological tissues with light and ultrasound based on layer-by-layer coating of silica optical fibers with a controlled degree of transparency. The time separation between optoacoustic and ultrasound signals collected with a custom-made spherical array transducer is exploited for simultaneous 3D optoacoustic and laser ultrasound (OPLUS) imaging with a single laser pulse. OPLUS is shown to enable large-scale anatomical characterization of tissues along with functional multi-spectral imaging of chromophores and assessment of cardiac dynamics at ultrafast rates only limited by the pulse repetition frequency of the laser. The suggested approach provides a flexible and scalable means for developing a new generation of systems synergistically combining the powerful capabilities of optoacoustics and ultrasound imaging in biology and medicine.

更新日期：2023-12-20

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