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Formation and Characterization of Z-Isomer-Enriched Carotenoid-Loaded Microparticles with Poly(vinylpyrrolidone) Using a Spray Drying Technique
Industrial & Engineering Chemistry Research ( IF 3.8 ) Pub Date : 2023-12-20 , DOI: 10.1021/acs.iecr.3c03450 Masaki Honda 1 , Yelin Zhang 1, 2 , Hakuto Kageyama 1, 3 , Takashi Hibino 1, 3 , Motonobu Goto 2, 4, 5 , Yasuhiro Nishida 6
Industrial & Engineering Chemistry Research ( IF 3.8 ) Pub Date : 2023-12-20 , DOI: 10.1021/acs.iecr.3c03450 Masaki Honda 1 , Yelin Zhang 1, 2 , Hakuto Kageyama 1, 3 , Takashi Hibino 1, 3 , Motonobu Goto 2, 4, 5 , Yasuhiro Nishida 6
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Carotenoid Z-isomers exhibit higher bioavailability and potentially beneficial biological activities than their all-E-isomers, which predominate in nature. However, they are chemically unstable and poorly soluble in water, which hinder the practical use of Z-isomer-enriched carotenoid materials. Encapsulating carotenoid Z-isomers in water-soluble carriers can overcome these problems. Here, we successfully prepared Z-isomer-enriched carotenoids (lycopene, β-carotene, and astaxanthin)/poly(vinylpyrrolidone) (PVP, a water-soluble polymer) inclusion complexes using a continuous-flow system which is constituted of a heated flow reactor and a spray dryer. Processing in the flow reactor at 200 °C for 15 s prior to spray drying improved the total Z-isomer ratio of the encapsulated carotenoids (>55%) and encapsulation efficiency of carotenoids in PVP. Furthermore, storage tests of the resulting complexes demonstrated that formulating (Z)-carotenoids with PVP stabilized their Z-structures. The results of this study contribute to the realization of industrial applications of Z-isomer-enriched carotenoids with great utility and health benefits.
中文翻译：
使用喷雾干燥技术用聚（乙烯基吡咯烷酮）形成和表征富含 Z 异构体的类胡萝卜素负载微粒
类胡萝卜素Z异构体比自然界中占主导地位的全E异构体表现出更高的生物利用度和潜在有益的生物活性。然而，它们化学不稳定且难溶于水，这阻碍了富含Z异构体的类胡萝卜素材料的实际应用。将类胡萝卜素Z-异构体封装在水溶性载体中可以克服这些问题。在这里，我们使用由加热流组成的连续流系统成功制备了富含Z异构体的类胡萝卜素（番茄红素、β-胡萝卜素和虾青素）/聚（乙烯基吡咯烷酮）（PVP，一种水溶性聚合物）包合物反应器和喷雾干燥器。喷雾干燥前在流动反应器中于 200 °C 处理 15 s，提高了包封的类胡萝卜素的Z异构体总比例 (>55%) 和 PVP 中类胡萝卜素的包封效率。此外，所得复合物的储存测试表明，用 PVP 配制 ( Z )-类胡萝卜素可稳定其Z结构。这项研究的结果有助于实现富含Z异构体的类胡萝卜素的工业应用，具有巨大的实用性和健康益处。
更新日期：2023-12-20
中文翻译：
使用喷雾干燥技术用聚（乙烯基吡咯烷酮）形成和表征富含 Z 异构体的类胡萝卜素负载微粒
类胡萝卜素Z异构体比自然界中占主导地位的全E异构体表现出更高的生物利用度和潜在有益的生物活性。然而，它们化学不稳定且难溶于水，这阻碍了富含Z异构体的类胡萝卜素材料的实际应用。将类胡萝卜素Z-异构体封装在水溶性载体中可以克服这些问题。在这里，我们使用由加热流组成的连续流系统成功制备了富含Z异构体的类胡萝卜素（番茄红素、β-胡萝卜素和虾青素）/聚（乙烯基吡咯烷酮）（PVP，一种水溶性聚合物）包合物反应器和喷雾干燥器。喷雾干燥前在流动反应器中于 200 °C 处理 15 s，提高了包封的类胡萝卜素的Z异构体总比例 (>55%) 和 PVP 中类胡萝卜素的包封效率。此外，所得复合物的储存测试表明，用 PVP 配制 ( Z )-类胡萝卜素可稳定其Z结构。这项研究的结果有助于实现富含Z异构体的类胡萝卜素的工业应用，具有巨大的实用性和健康益处。
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