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Oxidation-Responsive Polymeric Fluorinated Nanoparticles Prepared by Polymerization-Induced Self-Assembly
Macromolecules ( IF 5.1 ) Pub Date : 2023-12-19 , DOI: 10.1021/acs.macromol.3c01895 Yixin Chang 1 , Xin Xu 1 , Run Zhang 1 , Hui Peng 1 , Kun Liu 2 , Andrew K. Whittaker 1, 3 , Changkui Fu 1
Macromolecules ( IF 5.1 ) Pub Date : 2023-12-19 , DOI: 10.1021/acs.macromol.3c01895 Yixin Chang 1 , Xin Xu 1 , Run Zhang 1 , Hui Peng 1 , Kun Liu 2 , Andrew K. Whittaker 1, 3 , Changkui Fu 1
Affiliation
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Responsive polymeric nanoparticles have been extensively studied for various biological applications to provide enhanced function accuracy. Here, we report the synthesis of oxidation-responsive polymeric fluorinated nanoparticles (FNPs) via a photopolymerization-induced self-assembly (photo-PISA) method using a thioether- and fluorine-containing monomer N-(2-((2,2,2-trifluoroethyl)thio)ethyl)acrylamide (FTAM) and a methoxy polyethylene glycol (mPEG)-based macro chain transfer agent. With the polymerization of FTAM, the resultant block copolymer mPEG-b-PFTAM undergoes spontaneous self-assembly into spherical nanoparticles, driven by the solvophobic nature of the PFTAM block. The mobility of fluorine spins is highly restricted in the nanoparticles, leading to diminished 19F nuclear magnetic resonance (NMR)/magnetic resonance imaging (MRI) signals. However, when the nanoparticles are exposed to oxidants, the hydrophobic thioether groups of PFTAM can be oxidized into hydrophilic sulfoxide groups. This transition can lead to the disassembly of the PISA nanoparticles and switching on of the 19F NMR/MRI signals, owing to increased mobility of the fluorinated segments. This oxidation-responsive capability makes these polymeric FNPs useful for applications associated with oxidative conditions.
中文翻译：
聚合诱导自组装制备氧化响应型聚合物氟化纳米粒子
响应性聚合物纳米粒子已被广泛研究用于各种生物应用，以提供增强的功能准确性。在这里，我们报告了使用硫醚和含氟单体 N - (2-((2,2, 2-三氟乙基）硫代）乙基）丙烯酰胺（FTAM）和甲氧基聚乙二醇（mPEG）基大链转移剂。随着 FTAM 的聚合，所得嵌段共聚物 mPEG- b -PFTAM 在 PFTAM 嵌段的疏溶剂性质的驱动下自发自组装成球形纳米颗粒。氟自旋的迁移率在纳米颗粒中受到高度限制，导致19 F 核磁共振 (NMR)/磁共振成像 (MRI) 信号减弱。然而，当纳米粒子暴露于氧化剂时，PFTAM的疏水性硫醚基团可被氧化成亲水性亚砜基团。由于氟化链段的流动性增加，这种转变可以导致 PISA 纳米颗粒的分解并打开19 F NMR/MRI 信号。这种氧化响应能力使这些聚合 FNP 可用于与氧化条件相关的应用。
更新日期：2023-12-19
中文翻译：
聚合诱导自组装制备氧化响应型聚合物氟化纳米粒子
响应性聚合物纳米粒子已被广泛研究用于各种生物应用，以提供增强的功能准确性。在这里，我们报告了使用硫醚和含氟单体 N - (2-((2,2, 2-三氟乙基）硫代）乙基）丙烯酰胺（FTAM）和甲氧基聚乙二醇（mPEG）基大链转移剂。随着 FTAM 的聚合，所得嵌段共聚物 mPEG- b -PFTAM 在 PFTAM 嵌段的疏溶剂性质的驱动下自发自组装成球形纳米颗粒。氟自旋的迁移率在纳米颗粒中受到高度限制，导致19 F 核磁共振 (NMR)/磁共振成像 (MRI) 信号减弱。然而，当纳米粒子暴露于氧化剂时，PFTAM的疏水性硫醚基团可被氧化成亲水性亚砜基团。由于氟化链段的流动性增加，这种转变可以导致 PISA 纳米颗粒的分解并打开19 F NMR/MRI 信号。这种氧化响应能力使这些聚合 FNP 可用于与氧化条件相关的应用。
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