For an efficient tissue-engineered implant, it is mandatory to have appropriate fluid absorption and antibacterial properties. In this regard, polyurethane micro-nanofibers were modified by incorporating β-cyclodextrin by electrospinning and then adsorbed using silver (Ag) nanoparticles (NPs). We selected the adsorption by ultrasonication and hydrothermal methods and compared results for hydrophilicity, biodegradation, biocompatibility, and antibacterial activity. Scanning electron microscopy confirmed fiber diameter in mats with hydrothermally adsorbed Ag NPs was 8.0 ± 2.2 μm, and that of ultrasonically adsorbed Ag NPs was 4.0 ± 1.7 μm. The hydrophilicity results showed that incorporation of β-cyclodextrin in mats led to the decrease in water angle, and the Ag NPs adsorbed mats measured 53.50 ± 0.1° and 55.18 ± 0.15° at 1 min. The Ag NPs release by UV–visible spectroscopy indicated higher release in the case of ultrasonically adsorbed Ag NPs. Ultrasonically adsorbed Ag NPs showed higher antibacterial activity than hydrothermally against Staphylococcus aureus and Escherichia coli with 15 ± 2 mm and 12 ± 1 mm clear zones. The mouse fibroblasts showed a viability of >100 % in all mats, which determined that the fibers were biocompatible. The highest viability was seen in ultrasonically adsorbed Ag NP mats (262.76 ± 11.24 %). The cell attachment studies showed well-spread cells, concluding with excellent biocompatibility. Overall, results indicate ultrasonic adsorption is a straightforward and better strategy than hydrothermal treatment.

对于高效的组织工程植入物，必须具有适当的液体吸收和抗菌特性。在这方面，聚氨酯微纳米纤维通过静电纺丝掺入β-环糊精进行改性，然后用银（Ag）纳米粒子（NP）吸附。我们选择了超声吸附和水热法吸附，并比较了亲水性、生物降解性、生物相容性和抗菌活性的结果。扫描电子显微镜证实水热吸附银纳米粒子的纤维直径为 8.0 ± 2.2 μm，超声吸附银纳米粒子的纤维直径为 4.0 ± 1.7 μm。亲水性结果表明，在垫中掺入 β-环糊精导致水角降低，Ag NPs 吸附垫在 1 分钟时测得水角为 53.50 ± 0.1° 和 55.18 ± 0.15°。紫外可见光谱显示银纳米颗粒的释放表明，超声波吸附银纳米颗粒的释放量更高。超声波吸附的银纳米粒子对金黄色葡萄球菌和大肠杆菌。小鼠成纤维细胞在所有垫子中均显示出 >100% 的活力，这确定了该纤维具有生物相容性。超声波吸附的 Ag NP 垫中的活力最高 (262.76 ± 11.24%)。细胞附着研究显示细胞分布良好，具有优异的生物相容性。总的来说，结果表明超声波吸附是一种比水热处理更​​简单、更好的策略。