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Electrochemical Assembly of Nickel Metal Organic Framework-Decorated Nanoimprinted Gold Dendrites as Peroxidase Mimic for High-Performance Hydrogen Peroxide Sensing
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2023-12-18 , DOI: 10.1021/acsanm.3c05396 Shubhangi 1, 2 , Rohini Kumari 2 , S.K. Rai 1 , Pranjal Chandra 2
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2023-12-18 , DOI: 10.1021/acsanm.3c05396 Shubhangi 1, 2 , Rohini Kumari 2 , S.K. Rai 1 , Pranjal Chandra 2
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Hybrid nanomaterials with distinct properties and morphologies when clubbed within a sensor matrix can generate a synergistic effect on molecular sensing. In this work, creation of such nanohybrid platform has been attempted for rapid detection of hydrogen peroxide (H2O2), which has tremendous role in area of medical diagnostics. Conventionally, the peroxidase (POD) enzyme catalyzes H2O2; however, it is prone to inherent chemical and thermal instabilities reducing the overall stability and shelf life of sensor probe. A possible solution for this problem has been attempted in this work where a nonenzymatic peroxidase mimic nanohybrid probe comprising gold nanodendrites (AuND), nickel metal organic framework (Ni-MOF), and hydrazine has been synergistically deployed for rapid detection of H2O2. The developed sensor probe has been rigorously characterized through various characterization techniques, including scanning probe microscopy (SPM), scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX-mapping), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD), X-ray photoelectron spectroscopy (XPS), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). The probe demonstrated impressive analytical performance, possessing a linear dynamic range (LDR) between 1 × 10–8 M and 1 × 10–15 M and a limit of detection (LOD) of 0.34 (±0.05) × 10–15 M. The probe’s average response time with changing H2O2 concentrations was 5.02 ± 0.42 s, making it an agile sensing platform for H2O2 detection. The nanohybrid probe displayed minimal response toward interferants such as superoxide radicals, ascorbic acid, cysteine, glucose, alanine, and citric acid, which usually coexist in a real sample matrix. In order to investigate the real-life applicability of the developed sensor probe, a real sample analysis involving synthetic serum was adopted, which yielded a current recovery between 90.20 and 94.14%. The probe fabrication time and on-chip synthesis procedure are facile, making it a robust and efficient sensing platform for H2O2 free radicals in clinical settings.
中文翻译：
镍金属有机框架修饰的纳米压印金枝晶的电化学组装作为高性能过氧化氢传感的过氧化物酶模拟物
具有独特性质和形态的混合纳米材料在传感器矩阵中聚集时可以对分子传感产生协同效应。在这项工作中，我们尝试创建这种纳米混合平台来快速检测过氧化氢（H 2 O 2），这在医学诊断领域具有巨大的作用。传统上，过氧化物酶(POD)催化H 2 O 2；然而，它容易出现固有的化学和热不稳定性，从而降低传感器探头的整体稳定性和保质期。本工作尝试了该问题的可能解决方案，其中包含金纳米枝晶 (AuND)、镍金属有机框架 (Ni-MOF) 和肼的非酶过氧化物酶模拟纳米混合探针已协同部署用于快速检测 H 2 O 2。所开发的传感器探针已通过各种表征技术进行了严格表征，包括扫描探针显微镜 (SPM)、扫描电子显微镜 (SEM)、能量色散 X 射线分析 (EDX-mapping)、傅里叶变换红外光谱 (FTIR)、X-射线衍射分析（XRD）、X射线光电子能谱（XPS）、循环伏安法（CV）和电化学阻抗谱（EIS）。该探针表现出令人印象深刻的分析性能，线性动态范围 (LDR) 介于 1 × 10 –8 M 和 1 × 10 –15 M 之间，检测限 (LOD) 为 0.34 (±0.05) × 10 –15 M。探头对 H 2 O 2浓度变化的平均响应时间为 5.02 ± 0.42 s，使其成为 H 2 O 2检测的灵活传感平台。纳米混合探针对超氧自由基、抗坏血酸、半胱氨酸、葡萄糖、丙氨酸和柠檬酸等干扰物表现出最小的响应，这些干扰物通常共存于真实的样品基质中。为了研究所开发的传感器探针的实际适用性，采用了涉及合成血清的真实样品分析，其电流回收率在90.20%至94.14%之间。探针制造时间和片上合成程序都很简便，使其成为临床环境中强大且高效的 H 2 O 2自由基传感平台。
更新日期：2023-12-18
中文翻译：
镍金属有机框架修饰的纳米压印金枝晶的电化学组装作为高性能过氧化氢传感的过氧化物酶模拟物
具有独特性质和形态的混合纳米材料在传感器矩阵中聚集时可以对分子传感产生协同效应。在这项工作中，我们尝试创建这种纳米混合平台来快速检测过氧化氢（H 2 O 2），这在医学诊断领域具有巨大的作用。传统上，过氧化物酶(POD)催化H 2 O 2；然而，它容易出现固有的化学和热不稳定性，从而降低传感器探头的整体稳定性和保质期。本工作尝试了该问题的可能解决方案，其中包含金纳米枝晶 (AuND)、镍金属有机框架 (Ni-MOF) 和肼的非酶过氧化物酶模拟纳米混合探针已协同部署用于快速检测 H 2 O 2。所开发的传感器探针已通过各种表征技术进行了严格表征，包括扫描探针显微镜 (SPM)、扫描电子显微镜 (SEM)、能量色散 X 射线分析 (EDX-mapping)、傅里叶变换红外光谱 (FTIR)、X-射线衍射分析（XRD）、X射线光电子能谱（XPS）、循环伏安法（CV）和电化学阻抗谱（EIS）。该探针表现出令人印象深刻的分析性能，线性动态范围 (LDR) 介于 1 × 10 –8 M 和 1 × 10 –15 M 之间，检测限 (LOD) 为 0.34 (±0.05) × 10 –15 M。探头对 H 2 O 2浓度变化的平均响应时间为 5.02 ± 0.42 s，使其成为 H 2 O 2检测的灵活传感平台。纳米混合探针对超氧自由基、抗坏血酸、半胱氨酸、葡萄糖、丙氨酸和柠檬酸等干扰物表现出最小的响应，这些干扰物通常共存于真实的样品基质中。为了研究所开发的传感器探针的实际适用性，采用了涉及合成血清的真实样品分析，其电流回收率在90.20%至94.14%之间。探针制造时间和片上合成程序都很简便，使其成为临床环境中强大且高效的 H 2 O 2自由基传感平台。
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