Photoredox radical cyclization reaction of o-vinylaryl isocyanides with acyl chlorides to access 2,4-disubstituted quinolines,Organic & Biomolecular Chemistry

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Photoredox radical cyclization reaction of o-vinylaryl isocyanides with acyl chlorides to access 2,4-disubstituted quinolines
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2023-12-18 , DOI: 10.1039/d3ob01915b
Peng-Fei Huang ₁ , Jia-Le Fu ₁ , Jia-Jing Huang ₁ , Bi-Quan Xiong ₁ , Ke-Wen Tang ₁ , Yu Liu ₁

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We herein report an efficient photoredox radical cyclization reaction of o-vinylaryl isocyanides with acyl chlorides to access a wide range of 2,4-disubstituted quinolines. Preliminary mechanism experiment results suggested that this reaction was initiated by an acyl radical generated from acyl chlorides through a single-electron-transfer (SET) process. This transformation showed good substrate suitability and functional group compatibility at room temperature.

中文翻译：

邻乙烯基芳基异氰化物与酰氯的光氧化还原自由基环化反应生成2,4-二取代喹啉

我们在此报道了邻乙烯基芳基异氰化物与酰氯的有效光氧化还原自由基环化反应，以获得多种2,4-二取代喹啉。初步的机理实验结果表明，该反应是由酰氯通过单电子转移（SET）过程产生的酰基自由基引发的。该转化在室温下表现出良好的底物适应性和官能团相容性。

更新日期：2023-12-22

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