来自海藻 Agardhiella ramosissima 的硫酸化 iota 卡拉胶通过其抗氧化特性预防啮齿类动物的胃损伤,Algal Research

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来自海藻 Agardhiella ramosissima 的硫酸化 iota 卡拉胶通过其抗氧化特性预防啮齿类动物的胃损伤
Algal Research ( IF 4.6 ) Pub Date : 2023-12-17 , DOI: 10.1016/j.algal.2023.103371
João Lucas Silva Pinheiro , Lucas Henrique Marques Rodrigues , Lorena Duarte da Silva , Victória Martins Rodrigues dos Santos , Dayane Aparecida Gomes , Francisco Diego da Silva Chagas , Luciano de Sousa Chaves , Márcia Rúbia Silva Melo , Ana Lúcia Ponte Freitas , Marcellus Henrique Loiola Ponte Souza , Jand-Venes Rolim Medeiros , Renan Oliveira Silva Damasceno

在本研究中，研究了从海藻中分离出的硫酸化多糖（SP-Ar）对酒精性胃病的胃保护作用。还研究了胃的生理功能和体外抗氧化活性。结果发现，SP-Ar 显着减少了肉眼可见的损伤，并在组织学上维持了乙醇改变的胃上皮的结构，在 90 mg/kg 时效果最大。重要的是，用 SP-Ar 治疗的动物除了预防胃出血外，还保留了氧化状态，减少了非蛋白巯基 (NP-SH) 的消耗和丙二醛 (MDA) 的产生，降低了血管通透性。此外，SP-Ar给药不会改变胃分泌或排空。体外抗氧化数据表明，SP-Ar 具有较高的总抗氧化活性、DPPH 自由基清除能力和二价铁螯合能力。据观察，SP-Ar 通过防止形成或中和自由基来保护胃粘膜免受酒精性胃病的侵害，这与其内在的抗氧化活性有关。在这方面，这种大分子应该有可能作为一种新的治疗替代品或食品添加剂来增强胃粘膜的防御能力。

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Sulfated iota-carrageenan from marine alga Agardhiella ramosissima prevents gastric injury in rodents via its antioxidant properties

In the present study, the gastroprotective effect of a sulfated polysaccharide isolated from marine alga (SP-Ar) was investigated against alcoholic gastropathy. Gastric physiological functions and in vitro antioxidant activity also were studied. It was found that SP-Ar significantly reduced macroscopic injury and histologically maintained the architecture of gastric epithelium altered by ethanol, with maximum effect at 90 mg/kg. Importantly, animals treated with SP-Ar also had preservation of oxidative status, with reduction of nonprotein sulfhydryl groups (NP-SH) consumption and malondialdehyde (MDA) production, reduced vascular permeability, besides preventing gastric hemorrhage. In addition, SP-Ar administration did not modify gastric secretion or emptying. In vitro antioxidant data showed that SP-Ar presented high total antioxidant activity, DPPH radical scavenging, and ferrous iron chelating capacity. It was observed that SP-Ar protected gastric mucosa against alcoholic gastropathy by preventing the formation or neutralizing free radicals, associated with its intrinsic antioxidant activity. In this regard, this macromolecule should have possible application as a new therapeutic alternative or food additive to increase gastric mucosa defense.

更新日期：2023-12-17

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