The solubility of 4-guanidinobenzoic acid hydrochloride (4-GABCL) in pure solvents (H₂O, methanol, ethanol, n-propanol, isopropanol, 1-butanol, and 1-pentanol) and two binary solvents (H₂O + ethanol/isopropanol) were determined by the dynamic saturation method in the temperature range of 294.55 K–333.65 K under atmospheric pressure. From the measurement results, it could be observed that the solubility of 4-GABCL in both pure and binary solvents all increased with increasing temperature. The solubility order of 4-GABCL in pure solvents was ranked as follows: methanol > H₂O > n-propanol > ethanol > n-butanol > isopropanol > n-pentanol. The solubility of 4-GABCL in binary solvents tended to increase and then decrease with increasing molar fractions of ethanol and isopropanol, and the solubility of the solute in the binary solvents was greater than that of each in the monosolvents. In addition, Ideal model, Apelblat model, λh model, Wilson model, and NRTL model had been used to correlate the solubility of 4-GABCL in pure and binary solvents. Correlated effects show that the Wilson model gives the best correlation. The influence of solvents on the solubility of 4-GABCL was further studied by KAT-LSER model. The results showed that the solubility was mainly affected by the polarizability and the self-viscosity of the solvent.The mixing and dissolution thermodynamic properties of 4-GABCL in all experimental solvents had been calculated and analyzed by using the Wilson equation and solvent data. It was determined that the mixing and dissolution of 4-GABCL were spontaneous, endothermic and entropy-driven in the study systems. Besides, the solubility order of the pure solvent is consistent with the dissolution entropy at a temperature of 318.15 k.

4-胍基苯甲酸盐酸盐（4-GABCL）在纯溶剂（H ₂ O、甲醇、乙醇、正丙醇、异丙醇、1-丁醇和1-戊醇）和两种二元溶剂中的溶解度在常压、294.55 K~333.65 K温度范围内采用动态饱和法测定(H ₂ O + 乙醇/异丙醇)。从测量结果可以看出，4-GABCL在纯溶剂和二元溶剂中的溶解度均随着温度的升高而增加。 4-GABCL在纯溶剂中的溶解度顺序为：甲醇> H ₂ O>正丙醇>乙醇>正丁醇>异丙醇>正戊醇。 4-GABCL在二元溶剂中的溶解度随着乙醇和异丙醇摩尔分数的增加先增大后减小，且溶质在二元溶剂中的溶解度均大于在单溶剂中的溶解度。此外，还使用理想模型、Apelblat 模型、λh 模型、Wilson 模型和 NRTL 模型来关联 4-GABCL 在纯溶剂和二元溶剂中的溶解度。相关效应表明 Wilson 模型给出了最好的相关性。利用KAT-LSER模型进一步研究了溶剂对4-GABCL溶解度的影响。结果表明，溶解度主要受溶剂的极化性和自粘性的影响。利用Wilson方程和溶剂数据，对4-GABCL在所有实验溶剂中的混合和溶解热力学性质进行了计算和分析。结果表明，在研究系统中，4-GABCL 的混合和溶解是自发的、吸热的和熵驱动的。此外，纯溶剂的溶解度顺序与318.15 k温度下的溶解熵一致。