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Metallic artifacts-free spectral computed tomography angiography based on renal clearable bismuth chelate
Biomaterials ( IF 12.8 ) Pub Date : 2023-12-14 , DOI: 10.1016/j.biomaterials.2023.122422 Gang Shu 1 , Lu Zhao 2 , Fengtan Li 2 , Yingjian Jiang 2 , Xuening Zhang 3 , Chunshui Yu 2 , Jinbin Pan 2 , Shao-Kai Sun 4
Biomaterials ( IF 12.8 ) Pub Date : 2023-12-14 , DOI: 10.1016/j.biomaterials.2023.122422 Gang Shu 1 , Lu Zhao 2 , Fengtan Li 2 , Yingjian Jiang 2 , Xuening Zhang 3 , Chunshui Yu 2 , Jinbin Pan 2 , Shao-Kai Sun 4
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Computed tomography angiography (CTA) is one of the most important diagnosis techniques for various vascular diseases in clinic. However, metallic artifacts caused by metal implants and calcified plaques in more and more patients severely hinder its wide applications. Herein, we propose an improved metallic artifacts-free spectral CTA technique based on renal clearable bismuth chelate (Bi-DTPA dimeglumine) for the first time. Bi-DTPA dimeglumine owns the merits of ultra-simple synthetic process, approximately 100% of yield, large-scale production capability, good biocompatibility, and favorable renal clearable ability. More importantly, Bi-DTPA dimeglumine shows superior contrast-enhanced effect in CTA compared with clinical iohexol at a wide range of X-ray energies especially in higher X-ray energy. In rabbits’ model with metallic transplants, Bi-DTPA dimeglumine assisted-spectral CTA can not only effectively mitigate metallic artifacts by reducing beam hardening effect under high X-ray energy, but also enables accurate delineation of vascular structure. Our proposed strategy opens a revolutionary way to solve the bottleneck problem of metallic artifacts in CTA examinations.
中文翻译：
基于肾可清除铋螯合物的无金属伪影光谱计算机断层扫描血管造影
计算机断层扫描血管造影（CTA）是临床上对各种血管疾病最重要的诊断技术之一。然而，越来越多的患者因金属植入物和钙化斑块引起的金属伪影严重阻碍了其广泛应用。在此，我们首次提出了一种基于肾脏可清除的铋螯合物（Bi-DTPA 二葡胺）的改进的无金属伪影光谱 CTA 技术。 Bi-DTPA二葡胺具有合成工艺超简单、收率约100%、可规模化生产、良好的生物相容性、良好的肾清除能力等优点。更重要的是，与临床碘海醇相比，Bi-DTPA二葡胺在CTA中在较宽的X射线能量范围，特别是在较高的X射线能量下显示出优异的对比增强效果。在兔金属移植模型中，Bi-DTPA二甲胺辅助能谱CTA不仅可以通过减少高X射线能量下的束硬化效应来有效减轻金属伪影，而且可以准确勾画血管结构。我们提出的策略为解决 CTA 检查中金属伪影的瓶颈问题开辟了一条革命性的途径。
更新日期：2023-12-14
中文翻译：
基于肾可清除铋螯合物的无金属伪影光谱计算机断层扫描血管造影
计算机断层扫描血管造影（CTA）是临床上对各种血管疾病最重要的诊断技术之一。然而，越来越多的患者因金属植入物和钙化斑块引起的金属伪影严重阻碍了其广泛应用。在此，我们首次提出了一种基于肾脏可清除的铋螯合物（Bi-DTPA 二葡胺）的改进的无金属伪影光谱 CTA 技术。 Bi-DTPA二葡胺具有合成工艺超简单、收率约100%、可规模化生产、良好的生物相容性、良好的肾清除能力等优点。更重要的是，与临床碘海醇相比，Bi-DTPA二葡胺在CTA中在较宽的X射线能量范围，特别是在较高的X射线能量下显示出优异的对比增强效果。在兔金属移植模型中，Bi-DTPA二甲胺辅助能谱CTA不仅可以通过减少高X射线能量下的束硬化效应来有效减轻金属伪影，而且可以准确勾画血管结构。我们提出的策略为解决 CTA 检查中金属伪影的瓶颈问题开辟了一条革命性的途径。
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