Exendin-4：阿尔茨海默病和帕金森病的潜在治疗策略,Chemical Biology & Drug Design

当前位置： X-MOL 学术 › Chem. Bio. Drug Des. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Exendin-4：阿尔茨海默病和帕金森病的潜在治疗策略
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2023-12-15 , DOI: 10.1111/cbdd.14426
Aanchal Verma ₁ , Shobhit Chaudhary ₁ , Kunal Solanki ₁ , Ahsas Goyal ₁ , Harlokesh Narayan Yadav ₂

Affiliation

神经退行性疾病影响着全世界数百万人，其特点是选择性易感神经元的持续衰退。由于神经退行性疾病的病理过程复杂，目前尚无可行的神经退行性疾病治疗方法。因此，针对此类病症建立新的治疗方法仍然是临床空白。各种肽作为神经退行性疾病的神经保护干预措施的潜在意义正受到越来越多的关注。在过去几年中，由于胰高血糖素样肽 1 受体激动剂声称具有神经保护作用，科学界对它们的兴趣日益浓厚。Exendin-4 是一种胰高血糖素样肽-1 受体激动剂，已知具有抗糖尿病作用，并且数小时内不会降解，使其成为治疗此类疾病的最佳候选药物。此外，Exendin-4 的神经保护作用已在多项临床前研究中得到报道。Exendin-4 的多样化治疗靶点表明其在阿尔茨海默病和帕金森病等神经退行性疾病方面的潜在治疗用途，并引起了越来越多的关注。鉴于大量证据支持 exendin-4 在各种研究模型中的神经保护潜力，本文致力于探索 exendin-4 作为治疗药物治疗和管理阿尔茨海默病和帕金森病的前景。本综述从大量临床前和临床研究的结果中汲取见解，强调了 exendin-4 的集体神经保护优势及其神经保护作用的潜在机制。

"点击查看英文标题和摘要"

Exendin-4: A potential therapeutic strategy for Alzheimer's disease and Parkinson's disease

Neurodegenerative disorders, which affect millions worldwide, are marked by a steady decline of neurons that are selectively susceptible. Due to the complex pathological processes underlying neurodegeneration, at present, there is no viable therapy available for neurodegenerative disorders. Consequently, the establishment of a novel therapeutic approach for such conditions is a clinical void that remains. The potential significance of various peptides as neuroprotective interventions for neurodegenerative disorders is gaining increasing attention. In the past few years, there has been growing scientific interest in glucagon-like peptide-1 receptor agonists due to their claimed neuroprotective effects. Exendin-4 is a glucagon-like peptide-1 receptor agonist that is known to possess anti-diabetic effects and does not degrade for hours, making it a superior candidate for such disorders. Moreover, exendin-4's neuroprotective effects have been reported in several preclinical studies. Exendin-4's diverse therapeutic targets suggest its potential therapeutic uses in neurodegenerative ailments like Alzheimer's disease and Parkinson's disease and have garnered an increasing amount of attention. Given the substantial body of evidence supporting the neuroprotective potential of exendin-4 in various research models, this article is dedicated to exploring the promising role of exendin-4 as a therapeutic agent for the treatment and management of Alzheimer's disease and Parkinson's disease. This review draws insights from the findings of numerous preclinical and clinical studies to highlight the collective neuroprotective advantages of exendin-4 and the potential mechanisms that underlie its neuroprotective effects.

更新日期：2023-12-15

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>