Serum Bile Acids Improve Prediction of Alzheimer's Progression in a Sex-Dependent Manner,Advanced Science

当前位置： X-MOL 学术 › Adv. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Serum Bile Acids Improve Prediction of Alzheimer's Progression in a Sex-Dependent Manner
Advanced Science ( IF 14.3 ) Pub Date : 2023-12-13 , DOI: 10.1002/advs.202306576
Tianlu Chen ₁ , Lu Wang ₂ , Guoxiang Xie ₃ , Bruce S Kristal _{4,

5} , Xiaojiao Zheng ₁ , Tao Sun ₁ , Matthias Arnold _{6,

7} , Gregory Louie ₆ , Mengci Li ₁ , Lirong Wu ₁ , Siamak Mahmoudiandehkordi ₆ , Matthew J Sniatynski _{4,

5} , Kamil Borkowski ₈ , Qihao Guo ₁ , Junliang Kuang ₁ , Jieyi Wang ₁ , Kwangsik Nho ₉ , Zhenxing Ren ₁ , Alexandra Kueider-Paisley ₆ , Colette Blach ₁₀ , Rima Kaddurah-Daouk _{6,

11,

12} , Wei Jia _{1,

2} ,

Affiliation

Center for Translational Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, 999077, China.
Human Metabolomics Institute, Shenzhen, 518109, China.
Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Division of Sleep Medicine, Harvard Medical School, Boston, MA, 02115, USA.
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, 27710, USA.
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
West Coast Metabolomics Center, Genome Center, University of California Davis, Davis, CA, 95616, USA.
Department of Radiology and Imaging Sciences and the Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Duke Molecular Physiology Institute, Duke University, Durham, NC, 27708, USA.
Duke Institute of Brain Sciences, Duke University, Durham, NC, 27708, USA.
Department of Medicine, Duke University, Durham, NC, 27708, USA.

Sex disparities in serum bile acid (BA) levels and Alzheimer's disease (AD) prevalence have been established. However, the precise link between changes in serum BAs and AD development remains elusive. Here, authors quantitatively determined 33 serum BAs and 58 BA features in 4 219 samples collected from 1 180 participants from the Alzheimer's Disease Neuroimaging Initiative. The findings revealed that these BA features exhibited significant correlations with clinical stages, encompassing cognitively normal (CN), early and late mild cognitive impairment, and AD, as well as cognitive performance. Importantly, these associations are more pronounced in men than women. Among participants with progressive disease stages (n = 660), BAs underwent early changes in men, occurring before AD. By incorporating BA features into diagnostic and predictive models, positive enhancements are achieved for all models. The area under the receiver operating characteristic curve improved from 0.78 to 0.91 for men and from 0.76 to 0.83 for women for the differentiation of CN and AD. Additionally, the key findings are validated in a subset of participants (n = 578) with cerebrospinal fluid amyloid-beta and tau levels. These findings underscore the role of BAs in AD progression, offering potential improvements in the accuracy of AD prediction.

中文翻译：

血清胆汁酸以性别依赖性方式改善阿尔茨海默病进展的预测

血清胆汁酸（BA）水平和阿尔茨海默病（AD）患病率的性别差异已经确定。然而，血清 BA 的变化与 AD 发展之间的确切联系仍然难以捉摸。在这里，作者定量测定了从阿尔茨海默氏病神经影像计划的 1180 名参与者收集的 4219 个样本中的 33 种血清 BA 和 58 个 BA 特征。研究结果显示，这些 BA 特征与临床分期显着相关，包括认知正常 (CN)、早期和晚期轻度认知障碍、AD 以及认知表现。重要的是，这些关联在男性中比女性更明显。在处于疾病进展阶段的参与者中（n = 660），男性的 BA 发生了早期变化，发生在 AD 之前。通过将 BA 特征纳入诊断和预测模型，所有模型都得到了积极的增强。对于 CN 和 AD 的区分，男性接收者工作特征曲线下面积从 0.78 改善到 0.91，女性从 0.76 改善到 0.83。此外，关键发现在一组参与者 (n = 578) 脑脊液淀粉样蛋白-β 和 tau 水平中得到了验证。这些发现强调了 BA 在 AD 进展中的作用，为 AD 预测的准确性提供了潜在的改进。

更新日期：2023-12-13

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南