Despite the widely demonstrated public health benefits of contraception, limited contraceptive options are available for men, placing both the contraceptive burden and opportunity solely on women. This review outlines the need for an increased focus on male contraceptive development and highlights several related topics, including the perspectives of women and men on male contraceptives, historical challenges, and reasons behind the persistent delays in male contraceptive development. It also discusses the importance of serendipitous observations in drug discovery and the limitations of depleting sperm or spermatogenic cells as a contraceptive approach. It further provides an overview of ongoing research and development on novel methods, with a goal to offer insights into the multifaceted aspects of nonhormonal male contraceptive development, addressing its implications for the health of men and women.

尽管避孕的公共健康益处已得到广泛证明，但男性可选择的避孕方法有限，这使得避孕负担和机会全部落在女性身上。本综述概述了更加关注男性避孕药具开发的必要性，并强调了几个相关主题，包括女性和男性对男性避孕药具的看法、历史挑战以及男性避孕药具开发持续延迟背后的原因。它还讨论了药物发现中偶然观察的重要性以及消耗精子或生精细胞作为避孕方法的局限性。它还概述了正在进行的新方法的研究和开发，目的是深入了解非激素男性避孕药开发的多方面，解决其对男性和女性健康的影响。