We studied the effect of adrenoreceptor stimulation on the frequency of spontaneous activity and amplitude-time parameters of isometric contraction of the atrial myocardial strips from newborn rats, as well as the effect of Y receptor stimulation against the background of adrenoreceptor activation. After addition of Y_1,5 receptor agonist [Leu31, Pro34] NPY (10^—7 M), a tendency to a decrease in the effect of β_1,2-adrenoreceptor agonist isoproterenol (10^—5 M) on the frequency of spontaneous activity and atrial myocardial contractility was observed. The age-related features of the effect of NPY on the frequency of spontaneous activity and contractility of myocardial strips from newborn and adult rats were revealed.

我们研究了肾上腺素受体刺激对新生大鼠心房心肌条自发活动频率和等长收缩幅度-时间参数的影响，以及在肾上腺素受体激活背景下Y受体刺激的影响。添加 Y _1,5受体激动剂 [Leu31, Pro34] NPY (10 ^—7 M) 后，β _1,2 - 肾上腺素受体激动剂异丙肾上腺素 (10 ^—5 M) 对自发性频率的影响有降低的趋势观察活动和心房心肌收缩力。揭示了 NPY 对新生和成年大鼠心肌条自发活动频率和收缩力影响的年龄相关特征。