Selenated NHC-Pd(II) Pincer Complex Catalyzed, Temperature-Dependent Selective Hydroamination and Oxidative Amination of Olefins: Formation of Enamine Esters and β-Amino Esters under Solvent-Free and Aerobic Conditions,The Journal of Organic Chemistry

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Selenated NHC-Pd(II) Pincer Complex Catalyzed, Temperature-Dependent Selective Hydroamination and Oxidative Amination of Olefins: Formation of Enamine Esters and β-Amino Esters under Solvent-Free and Aerobic Conditions
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2023-12-12 , DOI: 10.1021/acs.joc.3c01706
Charu Sharma ₁ , Sangeeta Kumari ₁ , Deepak Sharma ₁ , Avinash K Srivastava ₁ , Raj K Joshi ₁

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NHC-Pd(II) pincer catalyzed oxidative amination and hydroamination of olefins is developed under solvent-free aerobic conditions. Reaction offered a temperature-controlled synthesis of (Z)-enamine and β-amino esters to provide easy access and remarkable functional group tolerance for a variety of enamines. The developed approach renders an opportunity of scalability and flexibility, and besides this, the produced enamines can be transformed into many N-containing heterocycles, underscoring its potential usage in synthetic and pharmaceutical chemistry. Moreover, it is the first report for coupling of aniline with styrene.

中文翻译：

硒化 NHC-Pd(II) 钳配合物催化的温度依赖性选择性氢胺化和氧化胺化烯烃：在无溶剂和有氧条件下形成烯胺酯和 β-氨基酯

NHC-Pd(II)钳催化烯烃氧化胺化和加氢胺化是在无溶剂有氧条件下开发的。 Reaction 提供了 ( Z )-烯胺和 β-氨基酯的温控合成，为各种烯胺提供了方便的获取和显着的官能团耐受性。所开发的方法提供了可扩展性和灵活性的机会，除此之外，产生的烯胺可以转化为许多含氮杂环，强调了其在合成和药物化学中的潜在用途。此外，这是首次报道苯胺与苯乙烯的偶联。

更新日期：2023-12-12

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