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Bioorthogonal Bond Cleavage Chemistry for On-demand Prodrug Activation: Opportunities and Challenges
Journal of Medicinal Chemistry ( IF 6.8 ) Pub Date : 2023-12-12 , DOI: 10.1021/acs.jmedchem.3c01459
Qingqiang Min 1 , Xingyue Ji 1
Journal of Medicinal Chemistry ( IF 6.8 ) Pub Date : 2023-12-12 , DOI: 10.1021/acs.jmedchem.3c01459
Qingqiang Min 1 , Xingyue Ji 1
Affiliation
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Time- and space-resolved drug delivery is highly demanded for cancer treatment, which, however, can barely be achieved with a traditional prodrug strategy. In recent years, the prodrug strategy based on a bioorthogonal bond cleavage chemistry has emerged with the advantages of high temporospatial resolution over drug activation and homogeneous activation irrespective of individual heterogeneity. In the past five years, tremendous progress has been witnessed in this field with one such bioorthogonal prodrug entering Phase II clinical trials. This Perspective aims to highlight these new advances (2019–2023) and critically discuss their pros and cons. In addition, the remaining challenges and potential strategic directions for future progress will also be included.
中文翻译：
用于按需前药激活的生物正交键断裂化学：机遇和挑战
癌症治疗非常需要时间和空间分辨的药物输送，然而，传统的前药策略几乎无法实现这一目标。近年来，基于生物正交键断裂化学的前药策略已经出现，其与药物激活相比具有高时空分辨率和不考虑个体异质性的均匀激活的优点。在过去五年中，该领域取得了巨大进展，其中一种生物正交前药进入了 II 期临床试验。本视角旨在强调这些新进展（2019-2023）并批判性地讨论它们的优缺点。此外，还将包括剩余的挑战和未来进展的潜在战略方向。
更新日期：2023-12-12
中文翻译：
用于按需前药激活的生物正交键断裂化学：机遇和挑战
癌症治疗非常需要时间和空间分辨的药物输送，然而，传统的前药策略几乎无法实现这一目标。近年来，基于生物正交键断裂化学的前药策略已经出现，其与药物激活相比具有高时空分辨率和不考虑个体异质性的均匀激活的优点。在过去五年中，该领域取得了巨大进展，其中一种生物正交前药进入了 II 期临床试验。本视角旨在强调这些新进展（2019-2023）并批判性地讨论它们的优缺点。此外，还将包括剩余的挑战和未来进展的潜在战略方向。
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