Targeting cap1 RNA methyltransferases as an antiviral strategy,Cell Chemical Biology

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Targeting cap1 RNA methyltransferases as an antiviral strategy
Cell Chemical Biology ( IF 6.6 ) Pub Date : 2023-12-12 , DOI: 10.1016/j.chembiol.2023.11.011
Yuta Tsukamoto ₁ , Manabu Igarashi ₂ , Hiroki Kato ₁

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Methylation is one of the critical modifications that regulates numerous biological processes. Guanine capping and methylation at the 7 position (mG) have been shown to mature mRNA for increased RNA stability and translational efficiency. The mG capped cap0 RNA remains immature and requires additional methylation at the first nucleotide (N1-2′--Me), designated as cap1, to achieve full maturation. This cap1 RNA with N1-2′--Me prevents its recognition by innate immune sensors as non-self. Viruses have also evolved various strategies to produce self-like capped RNAs with the N1-2′--Me that potentially evades the antiviral response and establishes an efficient replication. In this review, we focus on the importance of the presence of N1-2′--Me in viral RNAs and discuss the potential for drug development by targeting host and viral N1-2′--methyltransferases.

中文翻译：

靶向 cap1 RNA 甲基转移酶作为抗病毒策略

甲基化是调节众多生物过程的关键修饰之一。鸟嘌呤加帽和 7 位 (mG) 甲基化已被证明可以使 mRNA 成熟，从而提高 RNA 稳定性和翻译效率。 mG 加帽的 cap0 RNA 仍不成熟，需要在第一个核苷酸 (N1-2'-Me)（指定为 cap1）处进行额外的甲基化，以实现完全成熟。这种带有 N1-2′--Me 的 cap1 RNA 可防止先天免疫传感器将其识别为非自身。病毒还进化出了各种策略来产生带有 N1-2'-Me 的自样加帽 RNA，这可能会逃避抗病毒反应并建立有效的复制。在这篇综述中，我们重点关注病毒 RNA 中 N1-2'-Me 存在的重要性，并讨论了通过靶向宿主和病毒 N1-2'-甲基转移酶进行药物开发的潜力。

更新日期：2023-12-12

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