Picroside III Ameliorates Colitis in Mice: A Study Based on Colon Transcriptome and Fecal 16S Amplicon Profiling,Chemistry & Biodiversity

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Picroside III Ameliorates Colitis in Mice: A Study Based on Colon Transcriptome and Fecal 16S Amplicon Profiling
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2023-12-12 , DOI: 10.1002/cbdv.202301907
Yating Sun _{1,

2} , Yingdi Zhang _{1,

2} , Tao Wang _{1,

2} , Liping Wen ₃ , Tianhang Xing ₃ , Jiao Peng _{1,

2} , Yue Liang ₁

Affiliation

Cover Feature. Picrorhiza scrophulariiflora, a renowned bitter Chinese medicine, is known for its gastrointestinal thickening properties. Its active component, Picroside III (Pic), has demonstrated potential in ameliorating colitis. However, the precise mechanism of its action remains unclear. This study elucidates that Pic's favorable impact on colitis in mice is attributed to the inhibition of intestinal inflammation through the suppression of the PI3 K-Akt pathway. Additionally, it involves an elevation in the abundance of specific gut microbiota, namely Lactobacillus murinus and Lactobacillus gasseri, as reported by Yating Sun et al. in their research article at 10.1002/cbdv.202301806.

中文翻译：

黄连苷 III 改善小鼠结肠炎：基于结肠转录组和粪便 16S 扩增子分析的研究

封面特征。玄参是一种著名的苦味中药，以其胃肠粘稠特性而闻名。其活性成分胡黄连苷 III (Pic) 已被证明具有改善结肠炎的潜力。然而，其作用的确切机制仍不清楚。这项研究阐明，Pic 对小鼠结肠炎的有利影响归因于通过抑制 PI3 K-Akt 通路来抑制肠道炎症。此外，据 Yating Sun 等人报道，它还涉及特定肠道微生物群丰度的增加，即鼠乳杆菌和格氏乳杆菌。在他们的研究文章 10.1002/cbdv.202301806 中。

更新日期：2023-12-13

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