Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, and early diagnosis plays a crucial role in its prevention and treatment. In recent years, blood-based biomarkers for early AD diagnosis have gained attention due to their non-invasiveness and minimal adverse reactions, which make them an attractive approach. Since the onset of the COVID-19 pandemic, visiting large medical examination centers for blood tests has become increasingly challenging. The trend is shifting towards community or home-based sampling, which relies on the development and application of portable, miniaturized, and highly sensitive sensors. Among the various sensors used for detecting blood biomarkers in AD, printed sensors demonstrate great potential in AD blood biomarker detection due to their ease of miniaturization, scalability for mass production, and compatibility with various detection methods. In this review, we focus on discussing the application of printed sensors in the analysis of blood biomarkers for AD. We also explore the challenges faced by printed sensors in early diagnosis based on AD blood biomarkers and propose potential solutions to address these challenges.

阿尔茨海默病（AD）是一种慢性神经退行性疾病，早期诊断对其预防和治疗至关重要。近年来，用于早期 AD 诊断的血液生物标志物因其无创性和极低的不良反应而受到关注，这使其成为一种有吸引力的方法。自 COVID-19 大流行爆发以来，前往大型体检中心进行血液检查变得越来越困难。这一趋势正在转向社区或家庭采样，这依赖于便携式、小型化和高灵敏度传感器的开发和应用。在用于检测 AD 血液生物标志物的各种传感器中，印刷传感器由于其易于小型化、可大规模生产的可扩展性以及与各种检测方法的兼容性，在 AD 血液生物标志物检测中显示出巨大的潜力。在这篇综述中，我们重点讨论印刷传感器在 AD 血液生物标志物分析中的应用。我们还探讨了印刷传感器在基于 AD 血液生物标志物的早期诊断中所面临的挑战，并提出了应对这些挑战的潜在解决方案。