This review outlines progress in the synthesis of substituted naphthalene derivatives. Naphthalene and its derivatives exhibit various biological activities such as anti-inflammatory, anticancer, antiviral, antitubercular, antimicrobial, antihypertensive, antidiabetic, etc. Several strategies have been developed for the construction of naphthalene derivatives, primarily focused on metal-catalyzed reactions (palladium, copper, zinc, rhodium, platinum, nickel, etc.,) and Lewis acid catalyzed transformations. This review discusses the preparations of naphthalene derivatives using various salts such as gallium chlorides, gold chlorides, gold bromides, various gold complexes as well as Brønsted acids like triflic acid and trifluoroacetic acid, and Lewis acids such as boron trifluoride etherate. Additionally, miscellaneous types of reactions are explored involving both metal and Lewis acids. The transformational approaches covered in this review include cycloadditions, carboannulations, benzannulations, electroannulations, rearrangements, and cross-dehydrogenative coupling reactions. Overall this review provides a comprehensive and up-to-date account of the current state of preparations of substituted naphthalenes, highlighting their medicinal and industrial importance.

1 Introduction

1.1 Medicinal Importance of Naphthalenes

2 Synthesis of Substituted Naphthalenes

2.1 Metal-Catalyzed Reactions

2.1.1 Palladium-Catalyzed Reactions

2.1.2 Copper-Catalyzed Reactions

2.1.3 Zinc-Catalyzed Reactions

2.1.4 Iron-Catalyzed Reactions

2.1.5 Rhodium-Catalyzed Reactions

2.1.6 Platinum-Catalyzed Reactions

2.1.7 Nickel-Catalyzed Reactions

2.1.8 Other Metal-Catalyzed Reactions

3 Lewis Acid Catalyzed Reactions

4 Miscellaneous Reactions

5 Conclusion

本综述概述了取代萘衍生物的合成进展。萘及其衍生物表现出多种生物活性，如抗炎、抗癌、抗病毒、抗结核、抗菌、抗高血压、抗糖尿病等。已经开发了几种构建萘衍生物的策略，主要集中在金属催化反应（钯、铜、锌、铑、铂、镍等）和路易斯酸催化转化。本综述讨论了使用各种盐（例如氯化镓、氯化金、溴化金、各种金络合物）以及布朗斯台德酸（例如三氟甲磺酸和三氟乙酸）和路易斯酸（例如三氟化硼醚合物）制备萘衍生物。此外，还探索了涉及金属和路易斯酸的各种类型的反应。本综述涵盖的转化方法包括环加成、碳环化、苯并环化、电环化、重排和交叉脱氢偶联反应。总的来说，这篇综述对取代萘制剂的现状进行了全面和最新的描述，强调了它们的医学和工业重要性。

1 简介

1.1 萘的药用价值

2 取代萘的合成

2.1 金属催化反应

2.1.1 钯催化反应

2.1.2 铜催化反应

2.1.3 锌催化反应

2.1.4 铁催化反应

2.1.5 铑催化反应

2.1.6 铂催化反应

2.1.7 镍催化反应

2.1.8 其他金属催化反应

3 路易斯酸催化反应

4 杂项反应

5 结论