Nutritional intervention has been emerged as a popular strategy to improve quality of human life. Here we extracted and identified choerospondin (CHO), a dietary flavonoid glycoside from blossom of Citrus aurantium L. var. amara Engl. Different models were employed to screen the antioxidant, anti-tumor, anti-obesity, anti-inflammation and anti-atherosclerosis effects of CHO. The data showed that CHO displayed enhanced resistance to oxidative stress. Anti-proliferative effects against MCF-7, HepG2 and H1299 cells were also observed by CHO administration. CHO intervention potently inhibited 3 T3-L1 preadipocytes differentiation by suppressing transcription of some key adipogenic factors. Especially, CHO supplementation exhibited marked decreases of nitric oxide production in LPS-induced macrophages, significant reductions of cholesterol uptake and increases of cholesterol efflux in ox-LDL-loaded macrophages. These facts indicated that CHO showed greater anti-inflammation and anti-atherosclerosis potential. Futher, CHO markedly inhibited inflammatory responses through blunting mitogen-activated protein kinase phosphorylation and nuclear factor-kappa B activation. CHO application also reversed foam cell formation by regulating cluster of differentiation 36, phospholipid ATP-binding cassette transporter A1, phospholipid ATP-binding cassette transporter G1 and scavenger receptor class B type 1 expression. In conclusion, these data provided strong evidences that CHO possessed various pharmacological effects, including antioxidant, anti-tumor, anti-obesity and especially anti-inflammation and anti-atherosclerosis properties.

营养干预已成为改善人类生活质量的流行策略。在这里，我们从柑橘花中提取并鉴定了酸枣素（CHO），一种膳食黄酮苷。阿马拉英语。采用不同模型筛选CHO的抗氧化、抗肿瘤、抗肥胖、抗炎和抗动脉粥样硬化作用。数据表明，CHO 显示出增强的抗氧化应激能力。 CHO 给药也观察到对 MCF-7、HepG2 和 H1299 细胞的抗增殖作用。 CHO 干预通过抑制一些关键脂肪形成因子的转录，有效抑制 3 T3-L1 前脂肪细胞分化。特别是，补充 CHO 后，LPS 诱导的巨噬细胞中一氧化氮的产生显着减少，胆固醇摄取显着减少，负载 ox-LDL 的巨噬细胞中胆固醇流出增加。这些事实表明CHO表现出更大的抗炎和抗动脉粥样硬化潜力。此外，CHO 通过减弱丝裂原激活蛋白激酶磷酸化和核因子 kappa B 激活来显着抑制炎症反应。 CHO 应用还通过调节分化簇 36、磷脂 ATP 结合盒转运蛋白 A1、磷脂 ATP 结合盒转运蛋白 G1 和 B 类清道夫受体 1 型表达来逆转泡沫细胞形成。总之，这些数据有力地证明了 CHO 具有多种药理作用，包括抗氧化、抗肿瘤、抗肥胖，尤其是抗炎和抗动脉粥样硬化特性。