Data on trends in the epidemiological burden of bipolar disorder are scarce.

To provide an overview of trends in bipolar disorder burden from 1990 to 2019.

Revisiting the Global Burden of Disease Study 2019, we analysed the number of cases, calculated the age-standardised rate (per 100 000 population) and estimated annual percentage change (EAPC) of incidence, prevalence and years lived with disability (YLDs) for bipolar disorder from 1990 to 2019. The independent effects of age, period and cohort were estimated by the age–period–cohort modelling.

Globally, the bipolar disorder-related prevalent cases, incident cases and number of YLDs all increased from 1990 to 2019. Regionally, the World Health Organization Region of the Americas accounted for the highest estimated YLD number and rate, with the highest age-standardised prevalence rate in 1990 and 2019 and highest EAPC of prevalence. By sociodemographic index (SDI) quintiles, all five SDI regions saw an increase in estimated incident cases. Nationally, New Zealand reported the highest age-standardised rate of incidence, prevalence and YLDs in 1990 and 2019. The most prominent age effect on incidence rate was in those aged 15–19 years. Decreased effects of period on incidence, prevalence and YLD rates was observed overall and in females, not in males. The incidence, prevalence and YLD rates showed an unfavourable trend in the younger cohorts born after 1990, with males reporting a higher cohort risk than females.

From 1990 to 2019, the overall trend of bipolar disorder burden presents regional and national variations and differs by age, sex, period and cohort.

关于双相情感障碍流行病学负担趋势的数据很少。

概述 1990 年至 2019 年双相情感障碍负担的趋势。

回顾 2019 年全球疾病负担研究，我们分析了病例数，计算了双相情感障碍的年龄标准化率（每 10 万人）以及发病率、患病率和残疾寿命 (YLD) 的估计年度百分比变化 (EAPC) 1990 年至 2019 年的疾病。年龄、时期和队列的独立影响通过年龄-时期-队列模型进行估计。

从1990年到2019年，全球范围内双相情感障碍相关的流行病例、偶发病例和YLD数量均有所增加。从区域来看，世界卫生组织美洲地区的估计YLD数量和比率最高，年龄标准化患病率最高1990 年和 2019 年的发病率以及最高 EAPC 患病率。按社会人口指数 (SDI) 五分位数计算，所有五个 SDI 地区的估计事件病例数均有所增加。在全国范围内，新西兰在 1990 年和 2019 年报告了最高的年龄标准化发病率、患病率和 YLD。年龄对发病率影响最显着的是 15-19 岁人群。总体而言，女性（而非男性）中观察到经期对发病率、患病率和 YLD 率的影响有所减弱。 1990 年后出生的年轻队列的发病率、患病率和 YLD 率显示出不利的趋势，男性报告的队列风险高于女性。

1990年至2019年，双相情感障碍负担的总体趋势呈现地区和国家差异，并且因年龄、性别、时期和队列而异。