Antihyperglycemic and aphrodisiac effect of West African Albizia (Albizia zygia) leaves-inclusive diet in diabetes-induced erectile dysfunctional rats,Journal of Ethnopharmacology

当前位置： X-MOL 学术 › J. Ethnopharmacol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Antihyperglycemic and aphrodisiac effect of West African Albizia (Albizia zygia) leaves-inclusive diet in diabetes-induced erectile dysfunctional rats
Journal of Ethnopharmacology ( IF 4.8 ) Pub Date : 2023-12-09 , DOI: 10.1016/j.jep.2023.117562
Onyinyechi Ruth Nwagwe ₁ , Stephen Adeniyi Adefegha ₁ , Ganiyu Oboh ₁

Affiliation

Ethnopharmacological relevance

West African Albizia (Albizia zygia DC J. F. Macbr) leaves are a tropical plant that are frequently used in folkloric medicine to treat a number of illnesses, including type 2 diabetes (TY2D) and erectile dysfunction (ED), without having a complete scientific foundation. Aim of the study: This investigation examined the effect of action of dietary augmentation of Albizia zygia leaves (AZL) on rat sexual functioning and important enzymes related to TY2D and ED.

Materials and methods

Thirty matured adult Wistar rats of the weight 180–200 g were acclimatized in a lab environmental condition for two weeks prior to experiment given food and water to acclimate. Twenty-four of the rats got high fat diet (HFD) for periods of two weeks before receiving streptozotocin (STZ) intraperitoneally (i.p.), 35 mg/kg body weight single dose. Six rats got basal diets. Type 2 diabetes was identified in rats 72 h after STZ treatment. Rats were then used to evaluate the mounting number, mount delay, intromission number, and intromission latency.

Results

Following that, meals supplemented with AZL (5% or 10% inclusion) were given to diabetic-ED rats for 14 days. AZL was added. Therefore, in diabetic-ED rats, AZL supplementation could significantly (p0.05) lower blood glucose levels and the activities of alpha amylase, alpha glucosidase, phosphodiesterase-5, and arginase. In the case of diabetic-ED treated rats in consideration with diabetic-ED control group, nitric oxide levels were increased along with sexual function.

Conclusion

Thus, experimental results of this study demonstrated rats that consumed AZL in their diets had less erectile dysfunction. In order to address ED caused by diabetes, AZL could be suggested as functional meals.

中文翻译：

西非合欢 (Albizia zygia) 叶饮食对糖尿病引起的勃起功能障碍大鼠的降血糖和催情作用

民族药理学相关性

西非合欢 ( Albizia zygia DC JF Macbr) 叶是一种热带植物，在民间医学中经常用于治疗多种疾病，包括 2 型糖尿病 (TY2D) 和勃起功能障碍 (ED)，但没有完整的科学基础。研究目的：本研究探讨了合欢叶 (AZL) 饮食增强对大鼠性功能以及与 TY2D 和 ED 相关的重要酶的影响。

材料和方法

三十只体重为 180-200 克的成年 Wistar 大鼠在实验室环境条件下适应两周，然后给予食物和水以适应环境。 24 只大鼠接受高脂肪饮食 (HFD) 两周，然后腹膜内 (ip) 注射链脲佐菌素 (STZ)，单剂量 35 毫克/千克体重。六只大鼠接受基础饮食。 STZ 治疗后 72 小时，在大鼠中发现 2 型糖尿病。然后用大鼠评估安装次数、安装延迟、插入次数和插入潜伏期。

结果

此后，糖尿病 ED 大鼠接受补充 AZL（5% 或 10%）的膳食，持续 14 天。添加了AZL。因此，在糖尿病 ED 大鼠中，补充 AZL 可以显着（p0.05）降低血糖水平以及 α 淀粉酶、α 葡萄糖苷酶、磷酸二酯酶 5 和精氨酸酶的活性。在糖尿病性勃起功能障碍治疗的大鼠中，考虑到糖尿病性勃起功能障碍对照组，一氧化氮水平随着性功能的增加而增加。