Certain lactic acid bacteria have been utilized as bacteriostatic agents in the context of fruit and vegetable spoilage fungi. Although is a member of the lactic acid bacteria group, its application in the prevention of post-harvest fruit spoilage remains largely unexplored. We investigated the activity of cell-free supernatant (CFS) against fruit and vegetable spoilage fungi and probed the possible fungistatic mechanisms involved. The results showed that CFS possessed significant antifungal activity against with a MIC of 20%, which resulted in distorted rupture of cell membranes and leakage of cellular components in a dose-dependent manner. In addition, transcriptomics and metabolomics results showed that CFS could also inhibit the growth of by altering energy metabolism, impairing intracellular antioxidant function, reducing intracellular hormone biosynthesis, and slowing down or stopping asymmetric cell division. In summary, . CFS has been shown to effectively inhibit .

中文翻译：

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结合转录组学和代谢组学分析揭示屎肠球菌无细胞上清液抗链格孢菌的抗真菌活性和机制

某些乳酸菌已被用作水果和蔬菜腐败真菌的抑菌剂。尽管它是乳酸菌群的一员，但其在预防采后水果腐败方面的应用在很大程度上仍未得到探索。我们研究了无细胞上清液 (CFS) 对水果和蔬菜腐败真菌的活性，并探讨了可能的抑菌机制。结果表明，CFS具有显着的抗真菌活性，MIC为20%，导致细胞膜扭曲破裂和细胞成分渗漏，并呈剂量依赖性。此外，转录组学和代谢组学结果表明，CFS还可以通过改变能量代谢、损害细胞内抗氧化功能、减少细胞内激素生物合成、减缓或停止不对称细胞分裂来抑制生长。总之， 。 CFS已被证明可以有效抑制。