Molecular Machines For The Control Of Transmembrane Transport,Journal of the American Chemical Society

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Molecular Machines For The Control Of Transmembrane Transport
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2023-12-08 , DOI: 10.1021/jacs.3c08877
Toby G Johnson ₁ , Matthew J Langton ₁

Affiliation

Nature embeds some of its molecular machinery, including ion pumps, within lipid bilayer membranes. This has inspired chemists to attempt to develop synthetic analogues to exploit membrane confinement and transmembrane potential gradients, much like their biological cousins. In this perspective, we outline the various strategies by which molecular machines─molecular systems in which a nanomechanical motion is exploited for function─have been designed to be incorporated within lipid membranes and utilized to mediate transmembrane ion transport. We survey molecular machines spanning both switches and motors, those that act as mobile carriers or that are anchored within the membrane, mechanically interlocked molecules, and examples that are activated in response to external stimuli.

中文翻译：

控制跨膜运输的分子机器

大自然将一些分子机制（包括离子泵）嵌入脂质双层膜中。这启发化学家尝试开发合成类似物来利用膜限制和跨膜电位梯度，就像它们的生物表兄弟一样。从这个角度来看，我们概述了分子机器（利用纳米机械运动发挥功能的分子系统）的各种策略，这些策略被设计为纳入脂质膜并用于介导跨膜离子转运。我们研究了跨越开关和电机的分子机器，那些充当移动载体或锚定在膜内的分子机器，机械联锁的分子，以及响应外部刺激而激活的例子。

更新日期：2023-12-08

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