3,5,6-trichloropyridinol (TCPY) is a metabolite of chlorpyrifos and chlorpyrifos-methyl, whose presence in the environment is of potential toxicity to human. So, it is need to monitor and regualte TCPY levels to protect human health. However, it is not known whether TCPY is associated with all-cause and cancer mortality and to which degree its levels contributed to hazard risk. The study enrolled 3951 participants from the National Health and Nutrition Examination Surveys (NHANES). Ultra-high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry was used to measure urinary TCPY. Cox proportional hazards regression analysis was performed to explore the associations between TCPY and all-cause and cancer mortality. The study found that the average level of TCPY in the cohort was 1.79 μg/L and was higher in those who had passed away. Individuals in the highest quartile had a 1.56-fold independent increase in rate for all-cause mortality compared to those in the lowest quartile (hazard ratio [HR] 1.56, 95% confidence interval 1.09–2.24, p = 0.002). However, while the univariate model showed a hazard ratio of 2.37 (1.19–4.71) for the highest quartile in regards to cancer mortality, this association disappeared after adjusting for demographics, lifestyles, and comorbidities. Exposure to urinary 3,5,6-trichloropyridinol, as a result of insecticide exposure, increased the rate of all-cause mortality but was not independently associated with cancer mortality.

3,5,6-三氯吡啶醇（TCPY）是毒死蜱和甲基毒死蜱的代谢产物，其存在于环境中对人体具有潜在毒性。因此，需要监测和调节TCPY水平以保护人类健康。然而，尚不清楚 TCPY 是否与全因死亡率和癌症死亡率相关，以及其水平对危险风险的影响程度。该研究招募了来自国家健康和营养检查调查 (NHANES) 的 3951 名参与者。采用超高效液相色谱联合电喷雾电离串联质谱法测定尿 TCPY。进行 Cox 比例风险回归分析以探讨 TCPY 与全因死亡率和癌症死亡率之间的关联。研究发现，该队列中 TCPY 的平均水平为 1.79 μg/L，并且在已去世的人中更高。与最低四分位数的个体相比，最高四分位数的个体全因死亡率独立增加了 1.56 倍（风险比 [HR] 1.56，95% 置信区间 1.09–2.24，p = 0.002）。然而，虽然单变量模型显示癌症死亡率最高四分位的风险比为 2.37 (1.19-4.71)，但在调整人口统计、生活方式和合并症后，这种关联消失了。由于杀虫剂暴露而暴露于尿液中的 3,5,6-三氯吡啶醇会增加全因死亡率，但与癌症死亡率并不独立相关。