In an endeavor to pinpoint the structural constituents vital for the biological activity of 2,4-dihydroxy-5-methylphenyl ethanone, a series of its ether derivatives was synthesized and examined for their antifungal activities against five notable phytopathogenic fungi. The bioassay revealed that compounds 2, 3a, 3g, 3j and 3k manifested a broad spectrum of antifungal efficacy. Notably, compound 3g was identified as especially potent, with IC₅₀ values ranging from 16.52 to 37.52 μg/mL, outperforming the standard thiabendazole. The data underscore compound 3g as a prospective candidate for the development of an innovative antifungal agent. A comprehensive structure-activity relationship (SAR) study of the acetophenones was also conducted.

为了查明对 2,4-二羟基-5-甲基苯基乙酮生物活性至关重要的结构成分，合成了一系列其醚衍生物，并检查了它们对五种著名植物病原真菌的抗真菌活性。生物测定表明，化合物2、3a、3g、3j和3k表现出广谱的抗真菌功效。值得注意的是，化合物3g被认为特别有效，IC ₅₀值范围为 16.52 至 37.52  μg /mL，优于标准噻菌灵。该数据强调化合物3g作为开发创新抗真菌剂的潜在候选者。还对苯乙酮进行了全面的构效关系（SAR）研究。