Co-created in vivo pharmacology practical classes using the novel organism Lumbriculus variegatus,Pharmacology Research & Perspectives

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Co-created in vivo pharmacology practical classes using the novel organism Lumbriculus variegatus
Pharmacology Research & Perspectives ( IF 2.9 ) Pub Date : 2023-12-08 , DOI: 10.1002/prp2.1158
Julanta J Carriere ₁ , Nia A Davies ₁ , Margaret R Cunningham ₂ , Melisa J Wallace ₁ , Aidan Seeley ₁

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Co-creation within higher education emphasizes learner empowerment to promote collaboration between the students and staff, enabling students to become active participants in their learning process and the construction of resources with academic staff. Concurrently, a diminishing number of higher education institutions offer in vivo practical classes, resulting in an in vivo skills shortage. To address this, and to actively engage students in their own learning, we describe the co-creation of a student-led drug trial using Lumbriculus variegatus. Under blinded conditions, final-year undergraduate biomedical science students, under the tutelage of academic staff and fellow students, were involved in the co-creation of an in vivo practical class to determine the effects of histamine and histamine receptor inverse agonists mepyramine and loratadine. Throughout this process, undergraduate- and masters-level students played key roles in every aspect of practical delivery and data analysis. Herein, students demonstrated the test compounds, both in isolation and in combination, resulted in reduced stereotypical movements of L. variegatus (p < .05, n ≥ 6). 15% of students in the class responded to a feedback survey (n = 8) after the class. Students reported the class provided “real life” insights into in vivo research and enabled the development of hands-on skills which would be useful in applying in their future careers. All students reported that they enjoyed the class with 25% (n = 2) reporting concerns about animal use in research, enabling useful discussions about animals in research. Moreover, these student-led in vivo trials add to the pharmacological knowledge of L. variegatus promoting education-led research.

中文翻译：

使用新型生物 Lumbriculus variegatus 共同创建体内药理学实践课程

高等教育中的共同创造强调赋予学习者权力，以促进学生和教职员工之间的合作，使学生成为学习过程的积极参与者，并与学术人员一起构建资源。与此同时，提供体内实践课程的高等教育机构越来越少，导致体内技能短缺。为了解决这个问题，并让学生积极参与自己的学习，我们描述了使用Lumbriculus variegatus共同创建学生主导的药物试验。在盲法条件下，生物医学专业最后一年的学生在学术人员和同学的指导下，参与共同创建的体内实践课程，以确定组胺和组胺受体反向激动剂美吡拉敏和氯雷他定的作用。在整个过程中，本科生和硕士生在实践交付和数据分析的各个方面都发挥了关键作用。在此，学生们证明了测试化合物，无论是单独使用还是组合使用，都可以减少L. variegatus的刻板运动（ p < .05， n ≥ 6）。班上 15% 的学生在课后接受了反馈调查（ n = 8）。学生们表示，该课程提供了对体内研究的“现实生活”见解，并培养了实践技能，这对他们未来的职业生涯很有用。所有学生都表示他们很喜欢这门课程，其中 25%（ n = 2）的学生表示对研究中使用动物表示担忧，从而可以就研究中的动物进行有用的讨论。此外，这些学生主导的体内试验增加了L.的药理学知识。 variegatus 促进教育主导的研究。

更新日期：2023-12-08

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