Microvascular obstruction (MVO) often occurs in ST-elevation myocardial infarction (STEMI) patients after percutaneous coronary intervention (PCI). Diagnosis and treatment of MVO lack appropriate and established procedures. This study focused on two major points by using an in vitro multiscale flow model, which comprised an aortic root model with physiological blood flow and a microfluidic model of the microcirculation with vessel diameters down to 50 μm. First, the influence of porcine microthrombi (MT), injected into the fluidic microchip, on perfusion was investigated. We found that only of all injected MT were fully occlusive. Second, it could also be shown that the maximal concentration of a dye (representing therapeutic agent) during intracoronary infusion could be increased on average by , when proximally occluding the coronary artery by a balloon during drug infusion. The obtained results and insights enhance the understanding of perfusion in MVO-affected microcirculation and could lead to improved treatment methods for MVO patients.

中文翻译：

---

基于导管的药物输送在猪微血栓心脏微血管阻塞混合体外模型中的功效

微血管阻塞（MVO）常发生在ST段抬高型心肌梗死（STEMI）患者经皮冠状动脉介入治疗（PCI）后。MVO 的诊断和治疗缺乏适当且既定的程序。本研究利用体外多尺度血流模型，重点关注两个要点，包括具有生理血流的主动脉根模型和血管直径小至50μm的微循环微流体模型。首先，研究了注射到流体微芯片中的猪微血栓（MT）对灌注的影响。我们发现只有所有注射的 MT 均完全闭塞。其次，还可以证明，冠状动脉内输注期间染料（代表治疗剂）的最大浓度平均可以增加，在药物输注期间通过球囊近端闭塞冠状动脉时。获得的结果和见解增强了对受 MVO 影响的微循环灌注的理解，并可能改善 MVO 患者的治疗方法。