Multiple Non-Covalent Cross-Linked Multifunctional Strong Hemostatic Agent for Dynamic Exposure Hemostasis,Advanced Healthcare Materials

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Multiple Non-Covalent Cross-Linked Multifunctional Strong Hemostatic Agent for Dynamic Exposure Hemostasis
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2023-12-08 , DOI: 10.1002/adhm.202302574
Weijun Ji ₁ , Sidi Li ₂ , Xin Hou ₁ , Jin Zhao ₁ , Xubo Yuan ₁

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Trauma requires immediate hemostasis during primary care, as well as durable hemostasis that can withstand dynamic wound exposure. Although current hemostatic materials can treat bleeding sites in emergency situations, their mechanical strength and storage conditions limit their practical application. The simultaneous combination of good mechanical properties, storage stability, biocompatibility, and rapid hemostasis of hemostatic materials remains a challenge. In this paper, a novel hemostatic material based on multiple non-covalent bond crosslinking, which has excellent mechanical properties, good biocompatibility, storage stability, and rapid hemostasis ability, is reported. Under the drive of multiple non-covalent bonds, the flowability of hydrogel micro-modules (HM) decreases rapidly within 20 s after exposure to physiological saline. The HM form a gel barrier with a tensile strength of 62.10 kPa and an elongation at break of 1976% under multiple non-covalent bonding. Furthermore, the mechanical properties do not change significantly after 30 days of storage. Cell viability is maintained at over 80% after 3 days of incubation with the cells, and the hemolysis test shows a very low hemolysis rate (2.08%). The hemostatic gel formed by HM effectively prevents secondary bleeding in dynamic hemostasis experiments simulating transportation. This work provides a hemostatic material with comprehensive properties for practical applications.

中文翻译：

多种非共价交联多功能强效止血剂动态暴露止血

创伤需要在初级护理期间立即止血，以及能够承受动态伤口暴露的持久止血。尽管目前的止血材料可以在紧急情况下治疗出血部位，但其机械强度和储存条件限制了其实际应用。同时兼顾止血材料的良好机械性能、储存稳定性、生物相容性和快速止血仍然是一个挑战。本文报道了一种基于多重非共价键交联的新型止血材料，该材料具有优异的机械性能、良好的生物相容性、储存稳定性和快速止血能力。在多个非共价键的驱动下，水凝胶微模块（HM）的流动性在暴露于生理盐水后20 s内迅速下降。 HM在多重非共价键合下形成凝胶屏障，拉伸强度为62.10 kPa，断裂伸长率为1976%。此外，储存30天后机械性能没有明显变化。细胞孵育3天后，细胞活力维持在80%以上，溶血试验显示溶血率极低（2.08%）。 HM形成的止血凝胶在模拟运输的动态止血实验中有效防止二次出血。该工作为实际应用提供了一种具有综合性能的止血材料。

更新日期：2023-12-08

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