The triazole scaffold is a key element in heterocyclic chemistry, giving a fundamental building block in organic, medicinal chemistry, and material science. Triazole composed of a 5-membered heterocyclic ring with three N-atoms and two double bonds. Triazole fragment exhibits favourable bioavailability, facilitating the synthesis of wide range of compounds with excellent biological importance. Decades of research highlights the therapeutic potential, such as antibacterial, anti-inflammatory, cytotoxic, antitumor, and analgesic effects. This review focuses (2013–2023) on recent advancement in the synthesis of triazole derivatives from different nitrogen sources, and displaying their biological functions, structural modification, and bioavailability, emphasizing the importance of N-containing heterocycles in pharmaceuticals and sensing. Researchers, especially those who focused on the development of triazole derivatives with anticancer, antibacterial, antifungal, antitubercular and antiviral properties, will find this review is highly significant.

三唑支架是杂环化学的关键元素，是有机化学、药物化学和材料科学的基本组成部分。三唑由具有三个N原子和两个双键的5元杂环组成。三唑片段具有良好的生物利用度，有助于合成多种具有优异生物学重要性的化合物。数十年的研究凸显了其治疗潜力，例如抗菌、抗炎、细胞毒性、抗肿瘤和镇痛作用。本综述重点关注（2013-2023）不同氮源合成三唑衍生物的最新进展，并展示其生物学功能、结构修饰和生物利用度，强调含氮杂环在药物和传感中的重要性。研究人员，特别是那些专注于开发具有抗癌、抗菌、抗真菌、抗结核和抗病毒特性的三唑衍生物的研究人员，会发现这篇综述非常有意义。