Abstract

ction of 6-aryl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1,2-diones with 3-acetylcoumarins led to the formation of a new series of 1-[2-oxo-2-(2-oxo-2H-chromen-3-yl)ethylidene]-6-aryl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2(1H)-ones. Primary in vitro screening of anticoagulant activity against coagulation factors Xa and XIa was performed for all target compounds. The IC₅₀ value was also determined for the structures that showed the highest inhibition values among synthesized molecules.

中文翻译：

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6-芳基-5,6-二氢-4H-吡咯并[3,2,1-ij]喹啉-1,2-二酮类新型抗凝剂的合成与研究

摘要

6-芳基-5,6-二氢-4 H-吡咯并[3,2,1- ij ]喹啉-1,2-二酮与3-乙酰香豆素的反应导致形成一系列新的1-[2-氧代-2-(2-氧代-2H-苯并-3-基)亚乙基]-6-芳基-5,6-二氢-4H-吡咯并[3,2,1- ij ]喹啉-2( 1H）-那些。对所有目标化合物进行针对凝血因子 Xa 和 XIa 的抗凝血活性的初步体外筛选。还测定了合成分子中显示最高抑制值的结构的IC _50值。