Effect of CT-Guided Repeated Pulsed Radiofrequency on Controlling Acute/Subacute Zoster-Associated Pain: A Retrospective Cohort Study,Pain and Therapy

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Effect of CT-Guided Repeated Pulsed Radiofrequency on Controlling Acute/Subacute Zoster-Associated Pain: A Retrospective Cohort Study
Pain and Therapy ( IF 4.1 ) Pub Date : 2023-12-07 , DOI: 10.1007/s40122-023-00567-1
Min Rui ₁ , Zixin Han ₁ , Longsheng Xu ₁ , Ming Yao ₁

Affiliation

Introduction

Zoster-associated pain (ZAP) treatment and management is still inadequate. Repeated intervention protocol is often applied to manage ZAP. This study aimed to retrospectively investigate the effect of repeated applications of pulsed radiofrequency therapy on controlling acute/subacute ZAP.

Methods

From March 2019 to December 2021, 150 patients with acute/subacute ZAP who underwent repeated application of pulsed radiofrequency treatment (R-PRF) and pulsed radiofrequency combined paravertebral block interventions (PRF + PVB) in the Pain Department of the affiliated Hospital of Jiaxing University were enrolled. Patients were grouped by intervention protocol and received at least 12 months of follow-up assessments using the Numerical Rating Scale score (NRSs), Pittsburg Sleep Quality Index (PSQI), Simple McGill Pain Questionnaire-2 score (SF-MPQ-2s), and follow-up interventions.

Results

Both groups experienced a reduction in the incidence of clinically meaningful ZAP after the intervention therapy. In the R-PRF group, there were 36 cases of clinically meaningful ZAP within the first month post-treatment, while the PRF + PVB group had 38 cases. The incidence of clinically meaningful ZAP, as determined by multivariable generalized estimating equations, was 42.86% in the R-PRF group and 57.58% in the PRF + PVB group during the first month of follow-up. There was a significant difference in the incidence of clinically meaningful ZAP between the two groups after 1 month of treatment (adjusted odds ratio: 0.40; 95% confidence interval: 0.18–0.91; p = 0.03).

Conclusions

Both R-PRF and PRF + PVB treatments effectively relieve pain in patients with acute/subacute ZAP. However, R-PRF may have superior efficacy compared to PRF + PVB in reducing the incidence of clinically meaningful ZAP 1 month after treatment.

中文翻译：

CT 引导重复脉冲射频对控制急性/亚急性带状疱疹相关疼痛的效果：一项回顾性队列研究

介绍

带状疱疹相关疼痛（ZAP）的治疗和管理仍然不足。重复干预方案通常用于管理 ZAP。本研究旨在回顾性研究重复应用脉冲射频治疗对控制急性/亚急性ZAP的效果。

方法

2019年3月至2021年12月，嘉兴学院附属医院疼痛科重复应用脉冲射频治疗（R-PRF）和脉冲射频联合椎旁阻滞干预（PRF+PVB）的150例急性/亚急性ZAP患者被录取了。患者按照干预方案进行分组，并接受至少 12 个月的随访评估，使用数字评定量表评分 (NRS)、匹兹堡睡眠质量指数 (PSQI)、简单麦吉尔疼痛问卷 2 评分 (SF-MPQ-2s)、以及后续干预措施。

结果

干预治疗后，两组患者的具有临床意义的 ZAP 发生率均有所下降。在R-PRF组中，治疗后第一个月内有36例有临床意义的ZAP，而PRF+PVB组有38例。在随访的第一个月内，根据多变量广义估计方程确定的具有临床意义的 ZAP 发生率，R-PRF 组为 42.86%，PRF + PVB 组为 57.58%。治疗 1 个月后，两组之间有临床意义的 ZAP 发生率存在显着差异（调整优势比：0.40；95% 置信区间：0.18–0.91； p = 0.03）。