功能化发光MOF传感器的设计，用于精确监测人体体液和食品样本中的结核药物和新烟碱类农药，保护健康和环境,Journal of Materials Chemistry C

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功能化发光MOF传感器的设计，用于精确监测人体体液和食品样本中的结核药物和新烟碱类农药，保护健康和环境
Journal of Materials Chemistry C ( IF 5.7 ) Pub Date : 2023-12-06 , DOI: 10.1039/d3tc03712f
Abhijeet Rana ₁ , Nazir Ud Din Mir ₁ , Arpa Banik ₂ , Ananya Hazra ₁ , Shyam Biswas ₁

Affiliation

通过简单的处理方法以超低检测限选择性地检测饮用水和环境水源中的药物和农药仍然具有挑战性。为了克服这些挑战，我们使用2-(((2-羟基萘-1-基)甲基)氨基)对苯二甲酸(H_{2< /span>}L) 链接器。我们探索了无客体 MOF 在荧光检测广泛使用的新烟碱类农药（烯啶虫胺）和用于治疗结核病的非常常见的抗生素药物（利福平）方面的潜力。它是第一个基于 MOF 的荧光传感器，能够通过荧光关闭模式检测烯啶虫胺和利福平。与之前报道的烯啶虫胺和利福平传感探针相比，该探针具有较低的检测限（利福平的 LOD：11.7 nM 和烯啶虫胺：13.8 nM）。可瞬时（5秒内）检测烯啶虫胺和利福平。该探针的超快特性使其优于之前报道的耗时探针。这种传感器材料可回收五次，用于感测烯啶虫胺和利福平，从而提高了其成本效益和可持续性。这种化学性质稳定的 MOF 材料用于饮用水和环境水样品中分析物的荧光检测。该探针还可以精确定量人体血清和尿液中的利福平以及土壤和食品样品（大米和玉米）中的烯啶虫胺。在系统实验技术和分子模拟的帮助下，检测过程的机制已经被揭示。此外，还证明了探针检测两种分析物的重复性和再现性。整个工作提出了一种廉价且兼容的多用途烯啶虫胺和利福平光致发光传感器来解决现实世界的问题。

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Design of functionalized luminescent MOF sensor for the precise monitoring of tuberculosis drug and neonicotinoid pesticide from human body-fluids and food samples to protect health and environment

Selectively detecting pharmaceutical drugs and pesticides from drinking water and environmental water sources with an ultralow detection limit by a simple handling method remains challenging. To circumvent such challenges, we prepared an aluminum metal–organic framework (MOF) using 2-(((2-hydroxy naphthalene-1-yl)methyl)amino)terephthalic acid (H₂L) linker. We explored the potential of the guest-free MOF for the fluorescence detection of a broadly utilized neonicotinoid category of pesticide called nitenpyram and a very common antibiotic drug used for curing tuberculosis, namely rifampicin. It is the first MOF-based fluorescent sensor capable of detecting nitenpyram and rifampicin by fluorescent turn-off mode. This probe has lower detection limits (LOD for rifampicin: 11.7 nM and nitenpyram: 13.8 nM) as compared to those of formerly reported probes for nitenpyram and rifampicin sensing. It can detect nitenpyram and rifampicin instantaneously (within 5 s). The ultrafast nature of this probe makes it superior to the previously reported time-consuming probes. This sensor material is recyclable five times for sensing nitenpyram and rifampicin, boosting its cost-effectiveness and sustainability. This chemically robust MOF material was utilized for the fluorometric detection of both analytes in drinking water and environmental water samples. The probe can also precisely quantify rifampicin from human blood serum and urine and nitenpyram from soil and food samples (rice and corn). The mechanistic aspects of the detection process have been unveiled with the help of systematic experimental techniques and molecular simulations. In addition, the repeatability and reproducibility of the probe to sense both analytes were demonstrated. The overall work presents an inexpensive and compatible multiple-usable photoluminescent sensor of nitenpyram and rifampicin to address real-world issues.

更新日期：2023-12-06

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