<br>从基底前脑到腹侧被盖区的兴奋性投射是厌食症样表型的基础,Neuron

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从基底前脑到腹侧被盖区的兴奋性投射是厌食症样表型的基础
Neuron ( IF 14.7 ) Pub Date : 2023-12-05 , DOI: 10.1016/j.neuron.2023.11.001
Jing Cai ₁ , Yanyan Jiang ₂ , Yuanzhong Xu ₂ , Zhiying Jiang ₂ , Claire Young ₂ , Hongli Li ₂ , Joshua Ortiz-Guzman ₃ , Yizhou Zhuo ₄ , Yulong Li ₄ , Yong Xu ₅ , Benjamin R Arenkiel ₆ , Qingchun Tong ₇

Affiliation

Brown Foundation of Molecular Medicine for the Prevention of Human Diseases of McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA; MD Anderson Cancer Center & UTHealth Graduate School for Biomedical Sciences, University of Texas Health Science at Houston, Houston, TX 77030, USA.
Brown Foundation of Molecular Medicine for the Prevention of Human Diseases of McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Department of Molecular and Human Genetics and Department of Neuroscience, Baylor College of Medicine, and Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China.
USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Department of Molecular and Human Genetics and Department of Neuroscience, Baylor College of Medicine, and Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Brown Foundation of Molecular Medicine for the Prevention of Human Diseases of McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA; MD Anderson Cancer Center & UTHealth Graduate School for Biomedical Sciences, University of Texas Health Science at Houston, Houston, TX 77030, USA; Department of Neurobiology and Anatomy of McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

平衡内部能量需求和外部威胁线索的适应不良可能会导致饮食失调。然而，这种适应不良背后的大脑机制仍然难以捉摸。在这里，我们发现小鼠的基底前脑（BF）向腹侧被盖区（VTA）的谷氨酸能神经元发送谷氨酸能投射。两个区域的谷氨酸能神经元都对各种应激源表现出相关的反应。值得注意的是，对 VTA 中 BF 末端的操作表明，谷氨酸能 BF → VTA 回路会降低食欲、增加运动并引起回避。一致的是，VTA 谷氨酸能神经元的激活会减轻体重，削弱食物动机，并导致多动和焦虑行为迹象，这些都是典型厌食症症状的标志。重要的是，VTA 中 BF 谷氨酸能末端的激活减少了伏隔核中多巴胺的释放。总的来说，我们的结果表明，谷氨酸能 BF → VTA 回路的过度激活是导致多巴胺释放减少的厌食症样表型的潜在原因。

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更新日期：2023-12-05

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