Mechanochemical Iron-Catalyzed Nitrene Transfer Reactions: Direct Synthesis of N-Acyl Sulfonimidamides from Sulfinamides and Dioxazolones,Angewandte Chemie International Edition

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Mechanochemical Iron-Catalyzed Nitrene Transfer Reactions: Direct Synthesis of N-Acyl Sulfonimidamides from Sulfinamides and Dioxazolones
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-12-06 , DOI: 10.1002/anie.202316702
Shulei Pan ₁ , Florian F Mulks ₁ , Peng Wu ₁ , Kari Rissanen ₂ , Carsten Bolm ₁

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A mechanochemical nitrene transfer reaction towards N-acyl sulfonimidamides from sulfinamides and dioxazolones with the catalysis of iron(II) chloride is presented. This one-step solvent-free procedure shows better conversions rate and chemoselectivity compared to its solution-phase counterpart, providing a wide range of N-acyl sulfonimidamides in up to 87 % yield. Mechanistically, crucial nitrene iron complex intermediates are suggested by ESI-MS.

中文翻译：

机械化学铁催化氮烯转移反应：由亚磺酰胺和二恶唑酮直接合成 N-酰基磺酰亚胺

提出了在氯化铁 (II) 催化下，从亚磺酰胺和二恶唑酮向 N-酰基磺酰亚胺进行机械化学氮宾转移反应。与溶液相方法相比，这一一步式无溶剂程序显示出更好的转化率和化学选择性，可提供多种N-酰基磺酰亚胺，收率高达 87%。从机理上讲，ESI-MS 提示了关键的氮宾铁络合物中间体。

更新日期：2023-12-06

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