Investigating the Immune Basis of Green Tea Extract Induced Liver Injury in Healthy Donors Expressing HLA-B*35:01,Chemical Research in Toxicology

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Investigating the Immune Basis of Green Tea Extract Induced Liver Injury in Healthy Donors Expressing HLA-B*35:01
Chemical Research in Toxicology ( IF 3.7 ) Pub Date : 2023-12-06 , DOI: 10.1021/acs.chemrestox.3c00253
James Line ₁ , Serat-E Ali ₁ , Sophie Grice ₁ , Tai Rao _{1,

2,

3} , Dean J Naisbitt ₁

Affiliation

Epigallocatechin-3-O-gallate (EGCG) is the major component of green tea extract, commonly found in dietary supplements, and has been associated with immune-mediated liver injury. The purpose of this study was to investigate the immunogenicity of EGCG in healthy donors expressing HLA-B*35:01, and characterize EGCG responsive T-cell clones. We have shown that EGCG can prime peripheral blood mononuclear cells and T-cells from donors with and without the HLA-B*35:01 allele. T-cell clones were CD4^+ve and capable of secreting Th1, Th2, and cytolytic molecules. These data demonstrate that EGCG can activate T-cells in vitro, suggesting a significant role in the pathogenesis of green tea extract induced liver injury.

中文翻译：

研究绿茶提取物诱导表达 HLA-B 的健康供体肝损伤的免疫基础*35：01

表没食子儿茶素-3-O-没食子酸酯（EGCG）是绿茶提取物的主要成分，常见于膳食补充剂中，与免疫介导的肝损伤有关。本研究的目的是探讨 EGCG 在表达 HLA-B*35：01 的健康供体中的免疫原性，并表征 EGCG 反应性 T 细胞克隆。我们已经证明，EGCG 可以从有和没有 HLA-B*35：01 等位基因的供体中引发外周血单核细胞和 T 细胞。T 细胞克隆为 CD4^+ve，能够分泌 Th1 、 Th2 和溶细胞分子。这些数据表明，EGCG 可以在体外激活 T 细胞，表明在绿茶提取物诱导肝损伤的发病机制中起重要作用。

更新日期：2023-12-06

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