AbstractThe purpose of this article is to provide an overview of existing pharmacological models of canine dermatitis. Canine models of dermatitis have contributed significantly to our current understanding of the pathology of dermatitis and to the development of corresponding pharmacological interventions. Specifically, canine atopic dermatitis (AD) is reviewed here, as it is one of the most common inflammatory skin diseases in dogs. Canine AD also shares clinicopathological features with human AD, making the dog a natural and optimal model for human disease. Thus, pharmacological models of canine AD may be uniquely applicable to human pharmacological research. In this article, particular attention is dedicated to relevant in vivo, in vitro, and ex vivo models of canine AD, skin barrier defect models, pruritus models, and skin immunology models. Additionally, models of superficial pyoderma and food allergy are also discussed. With understanding of findings from canine models, researchers can select the most salient features for future pharmacological drug development. © 2023 Wiley Periodicals LLC.

中文翻译：

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犬炎症性皮肤病模型及其在药理研究中的应用

摘要本文的目的是概述现有的犬皮炎药理学模型。犬皮炎模型对我们目前对皮炎病理学的理解以及相应药物干预措施的开发做出了重大贡献。具体而言，本文将总结犬特应性皮炎 (AD)，因为它是犬类最常见的炎症性皮肤病之一。犬AD也与人类AD具有相同的临床病理特征，使狗成为人类疾病的天然最佳模型。因此，犬AD的药理学模型可能独特地适用于人类药理学研究。在本文中，特别关注相关体内,体外， 和离体犬AD模型、皮肤屏障缺陷模型、瘙痒症模型和皮肤免疫学模型。此外，还讨论了浅表脓皮病和食物过敏的模型。通过了解犬模型的研究结果，研究人员可以为未来的药理学药物开发选择最显着的特征。© 2023 Wiley 期刊有限责任公司。