Artemisia sieversiana Ehrhart ex Willd. Essential Oil and Its Main Component, Chamazulene: Their Photoprotective Effect against UVB-Induced Cellular Damage and Potential as Novel Natural Sunscreen Additives,ACS Sustainable Chemistry & Engineering

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Artemisia sieversiana Ehrhart ex Willd. Essential Oil and Its Main Component, Chamazulene: Their Photoprotective Effect against UVB-Induced Cellular Damage and Potential as Novel Natural Sunscreen Additives
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2023-12-05 , DOI: 10.1021/acssuschemeng.3c04804
Ying Zhou _{1,

2} , Lei He _{2,

3} , Wencui Wang _{1,

2} , Guodong Wei ₄ , Li Ma _{1,

2} , Huanyan Liu ₄ , Lei Yao _{1,

2}

Affiliation

In the modern cosmetic industry, there has been growing interest in developing plant-derived products for protecting human skin against ultraviolet (UV) radiation. This study was designated to evaluate Artemisia sieversiana Ehrhart ex Willd. essential oil (AEO) and its main component chamazulene (CHA) for their photoprotective effect in a human keratinocyte cell line (HaCaT), as well as their UVB-blocking efficacy. CHA was first refined from AEO by silica gel column chromatography and determined to be non-phototoxic. AEO and CHA exerted impressive protection on HaCaT cells against UVB associated with their antioxidant and anti-inflammatory properties. UVB-provoked cellular oxidative stress and inflammation response was alleviated by AEO and CHA since they mitigated endogenous antioxidant system depletion and mitochondrial depolarization and inhibited the expression of proinflammatory markers. Besides, AEO and its primary component CHA showed synergistic effects with two chemical UVB filters, suggesting their potential as new alternatives for chemical sunscreens. It should be mentioned that CHA is likely to be the major contributor of AEO in defending HaCaT cells and absorbing UVB rays. For now, our findings support the application of AEO, and especially CHA, in the design of new suncare products.

中文翻译：

艾蒿（Artemisia sieversiana Ehrhart ex Willd）。精油及其主要成分 Chamazulene：其对 UVB 引起的细胞损伤的光保护作用以及作为新型天然防晒添加剂的潜力

在现代化妆品行业，人们对开发植物源产品以保护人体皮肤免受紫外线 (UV) 辐射的兴趣日益浓厚。本研究旨在评估大叶蒿(Artemisia sieversiana Ehrhart ex Willd)。精油 (AEO) 及其主要成分 Chamazulene (CHA) 对人角质形成细胞系 (HaCaT) 具有光保护作用，并具有 UVB 阻挡功效。CHA首先通过硅胶柱色谱从AEO中精制出来，并被确定为无光毒性。AEO 和 CHA 对 HaCaT 细胞发挥了令人印象深刻的保护作用，使其免受 UVB 的侵害，这与其抗氧化和抗炎特性有关。AEO 和 CHA 减轻了 UVB 引发的细胞氧化应激和炎症反应，因为它们减轻了内源性抗氧化系统的消耗和线粒体去极化，并抑制了促炎标志物的表达。此外，AEO 及其主要成分 CHA 与两种化学 UVB 过滤剂表现出协同效应，表明它们具有作为化学防晒霜新替代品的潜力。值得一提的是，CHA 很可能是 AEO 防御 HaCaT 细胞和吸收 UVB 射线的主要贡献者。目前，我们的研究结果支持 AEO，尤其是 CHA 在新型防晒产品设计中的应用。

更新日期：2023-12-05

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