<br>饮食炎症指数 (DII) 与 2 型糖尿病患者慢性肾病患病率的关系。,Renal Failure

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饮食炎症指数 (DII) 与 2 型糖尿病患者慢性肾病患病率的关系。
Renal Failure ( IF 3.0 ) Pub Date : 2023-11-23 , DOI: 10.1080/0886022x.2023.2277828
Chunhua Guo ₁ , Yong Lin ₁ , Senchao Wu ₁ , Huaqing Li ₁ , Meng Wu ₁ , Fuzhen Wang ₁

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慢性肾脏病（CKD）是糖尿病（DM）的主要并发症。炎症是 DM 患者 CKD 进展过程中的重要组成部分。饮食是全身炎症水平的重要决定因素。然而，饮食炎症指数 (DII) 与 DM 患者中 CKD 之间的关联仍然很大程度上未知。因此，本研究的目的是探讨 DII 是否与 DM 患者中 CKD 的患病率相关。研究方法如下：首先，获得1999年至2018年国家健康与营养调查（NHANES）的数据。我们的研究共有 7,974 名参与者。然后根据 DII 三分位数 (T1-T3) 将这些人分为三组，每组由 2,658 名参与者组成。采用Logistic回归分析来检验DII和CKD之间是否存在联系。我们观察到 DM 患者的 DII 与 CKD 患病率之间存在显着相关性。全面调整年龄、性别、种族、吸烟、饮酒、体重指数（BMI）、甘油三酯（TG）、总胆固醇（TC）、代谢当量（MET）、能量摄入、降糖药物、高血压和心血管疾病后（ CVD），DII 较高的组有较高的 CKD 频率（T2 组：OR：1.40；95% CI：1.10-1.76；p = 0.006；T3 组：OR：1.67；95% CI：1.29-2.17； p < 0.001）。实施抗炎饮食可以作为 DM 患者预防 CKD 发病的干预策略。

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Association of the dietary inflammation index (DII) with the prevalence of chronic kidney disease in patients with type-2 diabetes mellitus.

Chronic kidney disease (CKD) is a major complication of diabetes mellitus (DM). Inflammation is an essential component in the process of CKD progression in patients with DM. Diet is a significant determinant of systemic inflammation levels. However, the association between the dietary inflammatory index (DII) and CKD in individuals with DM remains largely unknown; therefore, the aim of this study was to explore whether the DII is linked to the prevalence of CKD in patients with DM. The research method was as follows: first, data from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018 were obtained. There were 7,974 participants in our study. These individuals were then classified into three groups according to DII tertiles (T1-T3), with each group consisting of 2,658 participants. Logistic regression analysis was employed to examine whether there was a connection between the DII and CKD. We observed a significant association between the DII and the prevalence of CKD in individuals with DM. After full adjustment for age, sex, ethnicity, smoking, drinking, body mass index (BMI), triglyceride (TG), total cholesterol (TC), metabolic equivalents (METs), energy intake, hypoglycemic medications, hypertension, and cardiovascular disease (CVD), the group with a higher DII had a greater frequency of CKD (T2 group: OR: 1.40; 95% CI: 1.10-1.76; p = 0.006; T3 group: OR: 1.67; 95% CI: 1.29-2.17; p < 0.001). The implementation of an anti-inflammatory diet could serve as an intervention strategy for patients with DM to prevent the onset of CKD.

更新日期：2023-11-23

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