<br>Moslosooflavone 通过抑制氧化应激、神经炎症、能量代谢紊乱和细胞凋亡来预防低压缺氧引起的脑损伤。,Journal of Pharmacy and Pharmacology

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Moslosooflavone 通过抑制氧化应激、神经炎症、能量代谢紊乱和细胞凋亡来预防低压缺氧引起的脑损伤。
Journal of Pharmacy and Pharmacology ( IF 2.8 ) Pub Date : 2024-01-06 , DOI: 10.1093/jpp/rgad109
Jie Zhang _{1,

2} , Tong Zhao ₃ , Pengpeng Zhang ₂ , Zhiqun Shi ₂ , Qingyue Da _{1,

2} , Huiping Ma ₂ , Linlin Jing _{1,

2}

Affiliation

目的探讨莫洛索黄酮对小鼠低压缺氧（HH）所致脑损伤的保护作用。方法研究莫洛索黄酮对 HH 诱导的脑损伤小鼠氧化应激、神经炎症、能量代谢紊乱和细胞凋亡的保护作用。通过苏木精和伊红染色测定小鼠皮质的病理形态。 Western blot检测相关蛋白表达。主要发现 Moslosooflavone 改善了 HH 诱导的小鼠大脑组织病理学变化，降低了 ROS 和 MDA 的含量，并提高了 HH 暴露小鼠大脑中抗氧化酶和 GSH 的水平。 Moslosooflavone还显着增强HH暴露小鼠大脑中的ATP酶活性和PK、ATP含量，同时降低LDH活性和LD、TNF-α、IL-1β和IL-6含量。此外，莫洛索黄酮显着降低了 HH 暴露小鼠大脑中 HIF-1α、VEGF、Bax 和 cleaved caspase-3 的表达，显着增加了 Bcl-2、Nrf2 和 HO-1 的表达。结论我们目前的研究表明，莫洛索黄酮可能通过减轻氧化应激和神经炎症、维持能量代谢平衡和抑制细胞凋亡来保护HH引起的脑损伤。

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Moslosooflavone protects against brain injury induced by hypobaric hypoxic via suppressing oxidative stress, neuroinflammation, energy metabolism disorder, and apoptosis.

OBJECTIVES To investigate the protect effect of moslosooflavone against brain injury induced by hypobaric hypoxia (HH) in mice. METHODS Protective effects of moslosooflavone in oxidative stress, neuroinflammation, energy metabolism disorder, and apoptosis were studied in HH-induced brain damage mice. The pathological morphology in the cortex of mice was determined by hematoxylin and eosin staining. The related protein expressions were detected by western blot. KEY FINDINGS Moslosooflavone improved HH-induced brain histopathological changes, reduced the contents of ROS and MDA, and elevated the levels of antioxidant enzymes and GSH in HH-exposed brains of mice. Moslosooflavone also markedly enhanced the ATPase activities and PK, ATP contents, while reducing LDH activity and the LD, TNF-α, IL-1β, and IL-6 contents HH-exposed brains of mice. In addition, moslosooflavone notably decreased the expression of HIF-1α, VEGF, Bax, and cleaved caspase-3 dramatically increasing the expression of Bcl-2, Nrf2, and HO‑1 in HH-exposed brains of mice. CONCLUSIONS Our current studies indicate that moslosooflavone protects HH-induced brain injury possibly through alleviating oxidative stress and neuroinflammation, maintaining the balance of energy metabolism, and inhibiting cell apoptosis.

更新日期：2023-11-22

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