当前位置: X-MOL 学术Radiat. Phys. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Enhancement the dosimetric properties of N-(3-methoxypropyl) acrylamide polymer gel dosimeter for cancer treatment
Radiation Physics and Chemistry ( IF 2.8 ) Pub Date : 2023-12-04 , DOI: 10.1016/j.radphyschem.2023.111441
Khalid A. Rabaeh , Abdullah S. Bani Issa , Anas M. Ababneh , Molham M. Eyadeh

Recent studies related to the polymer gel dosimetry technique for radiation therapy have shown the importance of using additive of different concentrations to the polymer gel to improve the dose sensitivity. This work provides a significant improvement on the developed N-(3-methoxypropyl) acrylamide polymer gel dosimeter by incorporated with an inorganic salt of calcium chloride (CaCl2). Nuclear Magnetic Resonance relaxometry read out technique was used to examine dose-response after irradiation by measuring the change in the relaxation rate of R2. A medical linear accelerator with 6 MV photon beams and a 200 cGy/min dose rate was used to irradiate the developed gel with different absorbed doses. It was evidently clear from the findings that the R2 dose sensitivity of the developed polymer gel increased significantly by adding different concentrations of CaCl2 reaching 3.5 times higher than that without salt. The dose-response of the improved gel at various concentrations of co-monomer. Also, the dependency on the radiation dose rate, photon energy and irradiation temperature was investigated. Additionally, the stability of unirradiated as well as irradiated gel for 7-days post-irradiation was reported.



中文翻译:

增强用于癌症治疗的 N-(3-甲氧基丙基)丙烯酰胺聚合物凝胶剂量计的剂量学特性

最近与放射治疗聚合物凝胶剂量测定技术相关的研究表明,在聚合物凝胶中使用不同浓度的添加剂以提高剂量敏感性的重要性。这项工作通过掺入氯化钙(CaCl 2 )无机盐,对已开发的 N-(3-甲氧基丙基)丙烯酰胺聚合物凝胶剂量计进行了重大改进。核磁共振弛豫读出技术用于通过测量R 2弛豫率的变化来检查辐射后的剂量反应使用具有 6 MV 光子束和 200 cGy/min 剂量率的医用直线加速器以不同吸收剂量照射显影的凝胶。结果表明,添加不同浓度的CaCl 2后,所开发的聚合物凝胶的R 2剂量敏感性显着增加,达到不加盐的3.5倍。改进的凝胶在不同共聚单体浓度下的剂量反应。此外,还研究了对辐射剂量率、光子能量和照射温度的依赖性。此外,报告了未辐照和辐照凝胶在辐照后 7 天的稳定性。

更新日期:2023-12-04
down
wechat
bug