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One-step hydrothermal preparation of chiral carbon quantum dots and enantioselective sensing of glutamine enantiomeric isomers
Luminescence ( IF 3.2 ) Pub Date : 2023-12-02 , DOI: 10.1002/bio.4639 Xiang Li 1 , Jun Wu 1 , Xiashi Zhu 1
Luminescence ( IF 3.2 ) Pub Date : 2023-12-02 , DOI: 10.1002/bio.4639 Xiang Li 1 , Jun Wu 1 , Xiashi Zhu 1
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A novel method for chiral identification of glutamine enantiomers based on chiral carbon quantum dots (cCQDs) fluorescent probes. cCQDs were prepared using a one-step hydrothermal method with L-tryptophan as the carbon source and chiral source, producing spherical nanoparticles exhibiting a blue colour luminescence. The fluorescence intensity (F) of cCQDs was enhanced or quenched following the addition of chiral enantiomeric glutamine (L/D-Gln), and therefore cCQDs, as a fluorescence probe, could be used for enantioselective sensing of the L/D-Gln. The fluorescence enhancement value (∆FE) exhibited good linearity with L-Gln concentration in the range 0.23–10.00 mM, and the limit of detection was 0.14 mM. The fluorescence quenching value (∆FQ) showed a good linear relationship with D-Gln concentration in the range 0.29–10.00 mM, and the detection limit was 0.18 mM. The mechanism of fluorescence enhancement/quenching was explored by molecular modelling and the type of quenching. The method was applied to the determination of L-Gln content in real samples, and the recovery rate was satisfactory. This study provided a novel approach for the synthesis of cCQDs and the recognition of amino acid enantiomers.
中文翻译：
一步水热制备手性碳量子点及谷氨酰胺对映异构体的对映选择性传感
一种基于手性碳量子点（cCQD）荧光探针的谷氨酰胺对映体手性鉴定的新方法。以L-色氨酸为碳源和手性源，采用一步水热法制备cCQD，产生呈现蓝色发光的球形纳米粒子。添加手性对映体谷氨酰胺（L/D-Gln）后，cCQD 的荧光强度（F）增强或猝灭，因此 cCQD 作为荧光探针，可用于 L/D-Gln 的对映选择性传感。荧光增强值(ΔF E )与L-Gln浓度在0.23~10.00 mM范围内表现出良好的线性关系，检测限为0.14 mM。荧光猝灭值(ΔF Q )与D-Gln浓度在0.29~10.00 mM范围内呈良好的线性关系，检测限为0.18 mM。通过分子建模和猝灭类型探索了荧光增强/猝灭的机制。该方法用于实际样品中L-Gln含量的测定，回收率良好。该研究为cCQD的合成和氨基酸对映体的识别提供了一种新方法。
更新日期：2023-12-04
中文翻译：
一步水热制备手性碳量子点及谷氨酰胺对映异构体的对映选择性传感
一种基于手性碳量子点（cCQD）荧光探针的谷氨酰胺对映体手性鉴定的新方法。以L-色氨酸为碳源和手性源，采用一步水热法制备cCQD，产生呈现蓝色发光的球形纳米粒子。添加手性对映体谷氨酰胺（L/D-Gln）后，cCQD 的荧光强度（F）增强或猝灭，因此 cCQD 作为荧光探针，可用于 L/D-Gln 的对映选择性传感。荧光增强值(ΔF E )与L-Gln浓度在0.23~10.00 mM范围内表现出良好的线性关系，检测限为0.14 mM。荧光猝灭值(ΔF Q )与D-Gln浓度在0.29~10.00 mM范围内呈良好的线性关系，检测限为0.18 mM。通过分子建模和猝灭类型探索了荧光增强/猝灭的机制。该方法用于实际样品中L-Gln含量的测定，回收率良好。该研究为cCQD的合成和氨基酸对映体的识别提供了一种新方法。
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