Rationale: Respiratory resistance (Rrs) and reactance (Xrs) as measured by oscillometry and their intrabreath changes have emerged as sensitive parameters for detecting early pathological impairments during tidal breathing. Objectives: This study evaluates the prevalence and association of abnormal oscillometry parameters with respiratory symptoms and respiratory diseases in a general adult population. Methods: A total of 7,560 subjects in the Austrian LEAD (Lung, hEart, sociAl, boDy) Study with oscillometry measurements (computed with the Resmon Pro FULL; Restech Srl) were included in this study. The presence of respiratory symptoms and doctor-diagnosed respiratory diseases was assessed using an interview-based questionnaire. Rrs and Xrs at 5 Hz, their inspiratory and expiratory components, the area above the Xrs curve, and the presence of tidal expiratory flow limitation were analyzed. Normality ranges for oscillometry parameters were defined. Measurements and Main Results: The overall prevalence of abnormal oscillometry parameters was 20%. The incidence of abnormal oscillometry increased in the presence of symptoms or diagnoses: 17% (16-18%) versus 27% (25-29%), P < 0.0001. All abnormal oscillometry parameters except Rrs at 5 Hz were significantly associated with respiratory symptoms/diseases. Significant associations were found, even in subjects with normal spirometry, with abnormal oscillometry incidence rates increasing by 6% (4-8%; P < 0.0001) in subjects with symptoms or diagnoses. Conclusions: Abnormal oscillometry parameters are present in one-fifth of this adult population and are significantly associated with respiratory symptoms and disease. Our findings underscore the potential of oscillometry as a tool for detecting and evaluating respiratory impairments, even in individuals with normal spirometry.

中文翻译：

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示波法的诊断潜力：基于人群的方法。


理由：通过示波法测量的呼吸阻力 (Rrs) 和电抗 (Xrs) 及其呼吸内变化已成为检测潮式呼吸期间早期病理损伤的敏感参数。目的：本研究评估一般成年人群中异常示波参数与呼吸道症状和呼吸道疾病的患病率及其关联。方法：本研究纳入了奥地利 LEAD（肺、心脏、社会、身体）研究中使用示波测量（使用 Resmon Pro FULL；Restech Srl 计算）的总共 7,560 名受试者。使用基于访谈的问卷评估是否存在呼吸道症状和医生诊断的呼吸道疾病。分析了 5 Hz 时的 Rrs 和 Xrs、它们的吸气和呼气分量、Xrs 曲线上方的面积以及潮气呼气流量限制的存在。定义了示波参数的正态范围。测量和主要结果：示波参数异常的总体发生率为 20%。存在症状或诊断时，示波异常的发生率增加：17% (16-18%) 对比 27% (25-29%)，P < 0.0001。除 5 Hz 的 Rrs 外，所有异常示波参数均与呼吸道症状/疾病显着相关。即使在肺活量测定正常的受试者中也发现了显着的关联，在有症状或诊断的受试者中，示波测定异常发生率增加了 6%（4-8%；P < 0.0001）。结论：五分之一的成年人存在示波参数异常，并且与呼吸道症状和疾病显着相关。 我们的研究结果强调了示波测量法作为检测和评估呼吸损伤的工具的潜力，即使对于肺量测定正常的个体也是如此。