We would like to thank Wang et al for their insights and comments on our recently published manuscript ‘Definition of age-dependent reference values for the diameter of the common bile duct and pancreatic duct on MRCP: a population-based, cross-sectional cohort study’.1 2 We beg to differ: previously, body mass index (BMI) has been proposed as having a moderate influence on duct diameters (r<0.3).3 We assessed the impact of BMI together with sex, age and alanin-aminotransferase (ALAT) on the common bile duct (CBD) and pancreatic duct (PD) diameters in our study population using a multivariable quantile regression model (online supplemental table 21), but observed only very small effects. A 10 kg/m² increase in BMI was associated with a change in CBD or PD diameters of about 0.2 mm. Moreover, group differences in native or secretin-stimulated CBD and PD diameters among normal weight, overweight and obese individuals were not statistically significant (Kruskal-Wallis test p>0.05). We therefore included these participants in our …

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回复：Wang 等人关于“MRCP 上胆总管和胰管直径的年龄相关参考值的定义：仍需进一步讨论”的通信


我们要感谢 Wang 等人对我们最近发表的手稿“MRCP 上胆总管和胰管直径的年龄相关参考值的定义：一项基于人群的横断面队列研究”的见解和评论'.1 2 我们不敢苟同：以前，体重指数 (BMI) 被认为对导管直径有中等影响 (r<0.3)。3 我们评估了 BMI 与性别、年龄和丙氨酸的影响使用多变量分位数回归模型（在线补充表 21），观察了我们研究人群的转氨酶 (ALAT) 对胆总管 (CBD) 和胰管 (PD) 直径的影响，但仅观察到非常小的影响。 BMI每增加10公斤/平方米，CBD或PD直径就会变化约0.2毫米。此外，正常体重、超重和肥胖个体中天然或促胰液素刺激的 CBD 和 PD 直径的组间差异不具有统计学意义（Kruskal-Wallis 检验 p>0.05）。因此，我们将这些参与者纳入我们的……